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Postion:Product Catalog >PD180970
PD180970
  • PD180970

PD180970 NEW

Price $53 $88 $147
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: PD180970 CAS No.: 287204-45-9
Purity: 98.47% Supply Ability: 10g
Release date: 2024/11/06

Product Introduction

Bioactivity

名稱PD180970
描述PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia.
體外活性In K562 cells, PD180970 (0.5 μM) induces apoptosis and causes cell death. The IC50 values are 170, 80, and 80 nM for the tyrosine phosphorylation of p210Bcr-Abl, Gab2, and CrkL. PD180970 significantly inhibits the purified recombinant Abl tyrosine kinase activity with an IC50 of 2.2 nM[1]. In the human K562 CML cells, PD180970 inhibits the activity of Stat5 DNA-binding with an IC50 of 5 nM[2].
體內(nèi)活性In Male C57BL/6J mice injected with MPTP, intraperitonial injection of PD180970 (5?mg/kg) decreased number of activated microglia on activation by MPTP and reduces the Iba1 expression intensity in activated microglia[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 90.0 mg/mL (209.7 mM), Sonication is recommended.
關(guān)鍵字PD180970 | PD-180970
相關(guān)產(chǎn)品Gilteritinib | Nintedanib | Regorafenib monohydrate | Sorafenib | Pexidartinib | Ibrutinib | Regorafenib | Sorafenib tosylate | Lenvatinib mesylate | Imatinib | Pazopanib | Axitinib
相關(guān)庫經(jīng)典已知活性庫 | 酪氨酸激酶分子庫 | 激酶抑制劑庫 | 抗癌細(xì)胞代謝庫 | 抑制劑庫 | 已知活性化合物庫 | 細(xì)胞骨架化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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