PD 123319 NEW
| Price | $74 | $113 | $231 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: PD 123319 | CAS No.: 130663-39-7 |
| Purity: 98.75% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | PD 123319 |
| Description | PD 123319 ((S)-(+)-PD 123319) is a potent, selective AT2 angiotensin II receptor antagonist. |
| In vitro | Intravenous administration of PD 123319 to conscious hypertensive rats caused an immediate dose-dependent increase in MAP, and this effect was maintained for approximately 7.4 min with 3 mg/kg of PD 123319.PD 123319 had no effect on the self-regulation of cerebral blood flow. |
| In vivo | 125I-AII specifically labeled two classes of AII binding sites in bovine adrenal glomerular cell membrane preparations. The first class (DuP-753-sensitive) accounted for approximately 85% of the total AII binding sites and had a high affinity for DuP-753 (IC 50 of 92.9 nM).PD-123319 had no effect on the binding of 125I-AII to this site. The second type of binding site is more sensitive to PD-123319, with an IC50 of 6.9 nM, and has a much lower affinity for DuP-753 (IC50 of about 10 μM). |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (108.14 mM) H2O : 196.6 mM |
| Keywords | Angiotensin Receptor | inhibit | Inhibitor | PD-123319 | PD 123319 |
| Inhibitors Related | Olmesartan Medoxomil | Tranilast | Enalapril Maleate | Azilsartan Methyl Ester | Sacubitril/Valsartan | Azilsartan | Sinapinic Acid | Irbesartan | Losartan | Ramipril | Captopril | Valsartan Methyl Ester |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Angiogenesis related Compound Library | Inhibitor Library | Endocrinology-Hormone Compound Library | Anti-Cardiovascular Disease Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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