PARP-1-IN-2 NEW
| Price | $98 | $247 | $397 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: PARP-1-IN-2 | CAS No.: 684234-55-7 |
| Purity: 98.82% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | PARP-1-IN-2 |
| 描述 | PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells. |
| 體外活性 | PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) exhibits significant anti-proliferative activity against A549 cells without notable cytotoxicity on HFF cells.[1] PARP-1-IN-2 (0-10 μM, 24 h) reduces pro-caspase-3 and phosphorylated AKT expression, while increasing caspase-3, caspase-9 protein, and cleaved PARP-1 expression.[1] |
| 存儲(chǔ)條件 | Shipping with blue ice. |
| 溶解度 | DMSO : 9 mg/mL (21.21 mM), Sonication is recommended. |
| 相關(guān)產(chǎn)品 | 4'-Methoxychalcone | Niraparib tosylate monohyrate | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | 3-Methoxybenzamide | NU1025 | Olaparib | Benzamide | Picolinamide | OUL35 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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