Product Details
| Product Name:
Pancopride |
CAS No.:
121650-80-4 |
| Purity:
93.64% |
Supply Ability:
10g |
| Release date:
2024/11/20 |
Product Introduction
Bioactivity
| Name | Pancopride |
| Description | Pancopride（LAS 30451） is a novel, orally available, long-acting, selective 5-HT3 receptor antagonist that blocks nitrogen mustard and dacarbazine-induced vomiting. |
| In vitro | Pancopride, a new potent and selective 5-HT3 receptor antagonist, is effective orally and parenterally against cytotoxic drug-induced emesis. It exhibited high affinity (Ki=0.40 nM) for [3H]GR65630-labelled 5-HT3 recognition sites in membranes from the cortex of rat brains[2]. |
| In vivo | Pancopride, when administered i.v. 5 minutes before 5-HT challenge, antagonizes 5-HT-induced bradycardia in anaesthetized rats (ID50=0.56 μg/kg) and, when given p.o. 60 minutes before 5-HT challenge, displays similar antagonistic effects (ID50=8.7 μg/kg). A single oral dose of Pancopride (10 μg/kg) significantly inhibits the bradycardic reflex over an 8-hour period. In dogs, Pancopride dose-dependently inhibits the number of vomiting episodes and delays the onset of vomiting induced by cisplatin (ID50=3.6 μg/kg i.v. and 7.1 μg/kg p.o.)[1]. Pancopride not only inhibits vomiting induced by cisplatin in dogs but is also effective in blocking mechloretamine- and dacarbazine-induced emesis without exhibiting any antidopaminergic activity. Additionally, Pancopride stimulates gastric emptying of glass beads in rats (DE50=0.032 mg/kg p.o.). Furthermore, Pancopride (1 mg/kg i.p.) reverses cisplatin-induced slowing of gastric emptying in rats[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | LAS30451 | Pancopride | LAS-30451 |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | CLOZAPINE N-OXIDE | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
Recommended supplier
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Price |
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Suppliers |
Update time |
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$/ |
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Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States