Pachymic acid NEW
| Price | $72 | $177 | $277 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Pachymic acid | CAS No.: 29070-92-6 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Pachymic acid |
| Description | Pachymic acid (3-O-Acetyltumulosic acid) is a natural product, and inhibits Akt and ERK signaling pathways. |
| Cell Research | The anti-proliferative ability of PA on lung cancer cells was assessed by MTT, colony formation and EdU proliferation assays; cell cycle changes were detected by flow cytometry; apoptosis was detected by annexin V/PI double staining and DNA laddering; and the expression of apoptosis-related proteins was analyzed by Western blotting [1]. |
| In vitro | Porinic acid (PA) exerted antitumor effects on NCI-H23 and NCI-H460 lung cancer cells in vitro, while inducing cellular G2/M phase arrest and apoptosis. Our data showed that PA induced reactive oxygen species (ROS) production, leading to activation of c-Jun N-terminal kinase (JNK) and endoplasmic reticulum (ER) stress apoptotic pathways in lung cancer cells. Furthermore, blocking ROS production reversed PA-induced JNK and ER stress activation. Finally, PA inhibited the growth of NCI-H23 xenograft tumors without causing any toxicity to the host, and suppressed cell proliferation and induced apoptosis in tumor xenograft tissues [1]. At the same time, PA induced cell cycle arrest at G0 phase.PA also significantly inhibited cancer cell migration and invasion in a dose-dependent manner. Interestingly, PA inhibited the adhesion ability of cancer cells in a dose-dependent manner, which may contribute to the inhibition of cell invasion. Finally, it was shown that PA inhibited AKT and ERK signaling pathways. And tumor proteins such as PCNA, ICAM-1 and RhoA, which are involved in tumorigenesis, were also down-regulated by PA [1]. |
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 1 mg/ml, Sonication is recommended. |
| Keywords | Pachymic acid | PKB | Protein kinase B | inhibit | Akt | ERK | Extracellular signal regulated kinases | Inhibitor |
| Inhibitors Related | TBHQ | Ethyl gallate | Notoginsenoside R1 | Oridonin | Capivasertib | Lidocaine | Astragaloside IV | Lidocaine hydrochloride | Artemisinin | Honokiol | Tauroursodeoxycholate | 2,3-Butanediol |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Kinase Inhibitor Library | Natural Product Library | Inhibitor Library | Microbial Natural Product Library | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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