Product Details
| Product Name:
OD36 |
CAS No.:
1638644-62-8 |
| Purity:
99.89% |
Supply Ability:
10g |
| Release date:
2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | OD36 |
| 描述 | OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket. |
| 體外活性 | OD36 shows activity against ALK1 (KD=90 nM).[2]
OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2]
OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2]
OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2] |
| 體內(nèi)活性 | OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically neutrophils, and to a lesser extent, lymphocytes. It decreased RIPK2-specific genes, as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3] |
| 存儲(chǔ)條件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 25 mg/mL (75.58 mM), Sonication and heating are recommended.
|
| 關(guān)鍵字 | OD36 Hydrochloride | OD 36 Hydrochloride | OD36 | OD-36 Hydrochloride |
| 相關(guān)產(chǎn)品 | Alectinib hydrochloride | Lorlatinib | SB-431542 | DMH-1 | PK68 | RepSox | Oditrasertib | Crizotinib | LY-364947 | Ceritinib | A 83-01 | ALK-IN-1 |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$1680.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2024-10-28 |
United States