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Postion:Product Catalog >Natural Products>Alkaloids>O-Nornuciferine
O-Nornuciferine
  • O-Nornuciferine

O-Nornuciferine NEW

Price $81 $198 $328
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: O-Nornuciferine CAS No.: 3153-55-7
Purity: 99.86% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

NameO-Nornuciferine
DescriptionO-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
In vitroIn an in vitro screening of herbal materials for hERG blockers using an automated two-microelectrode voltage clamp assay on Xenopus oocytes, an alkaloid fraction of Nelumbo nucifera Gaertn. (lotus) leaves induced ???50% of hERG current inhibition at 100 μg/mL. Chromatographic separation resulted in the isolation and identification of (-)-asimilobine, 1, nuciferine, 2, O-Nornuciferine, 3, N-nornuciferine, 4, and liensinine, 5. In agreement with in silico predicted ligand-target interactions, 2, 3, and 4 revealed distinct in vitro hERG blockages measured in HEK293 cells with IC50 values of 2.89, 7.91, and 9.75 μM, respectively.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 50 mg/mL (177.71 mM)
KeywordsInhibitor | Potassium Channel | O-Nornuciferine | KcsA | inhibit | ONornuciferine | O Nornuciferine
Inhibitors RelatedMinoxidil sulfate | Glibenclamide | (±)-Naringenin | Tetraethylammonium bromide | Halothane | Butamben | Neratinib | Cloperastine hydrochloride | 2,2,2-Trichloroethanol | Indapamide
Related Compound Libraries經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 中藥單體化合物庫 | 稀有天然產(chǎn)物庫 | 生物堿類天然產(chǎn)物庫 | 植物來源化合物庫 | 中藥抗炎分子庫 | 離子通道庫 | 古代經(jīng)典名方目錄分子庫 | 藥食同源庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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