NPS-2143 hydrochloride NEW
| Price | $38 | $84 | $128 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: NPS-2143 hydrochloride | CAS No.: 324523-20-8 |
| Purity: 99.38% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | NPS-2143 hydrochloride |
| 描述 | NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist. |
| 體外活性 | NPS 2143, even when tested at much higher concentrations (3 microM), did not affect the activity of a number of other G protein-coupled receptors, including those most structurally homologous to the Ca2+ receptor. NPS 2143 stimulated parathyroid hormone (PTH) secretion from bovine parathyroid cells (EC50 of 41 nM) over a range of extracellular Ca2+ concentrations and reversed the effects of the calcimimetic compound NPS R-467 on [Ca2+]i and on secretion of PTH . The first reported calcilytic compound was NPS 2143, an orally active molecule which elicits rapid, 3- to 4-fold increases in circulating levels of PTH. |
| 體內(nèi)活性 | When intravenously administered to normal rats, NPS 2143 swiftly elevated plasma PTH levels significantly. Known as calcilytics, substances like NPS 2143 act as Ca2+ receptor antagonists, with it being the inaugural compound (either atomic or molecular) identified with this activity [1]. Concurrent administration with an antiresorptive agent (estradiol) resulted in enhanced trabecular bone volume and bone mineral density in osteopenic rats. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (112.26 mM) |
| 關(guān)鍵字 | NPS2143 | NPS 2143 Hydrochloride | NPS2143 Hydrochloride | NPS-2143 | CaSR | NPS 2143 hydrochloride | Calcium-sensing receptor | inhibit | SB-262470A | Inhibitor | NPS-2143 Hydrochloride | NPS 2143 | NPS2143 hydrochloride |
| 相關(guān)產(chǎn)品 | SB-423562 | Strontium ranelate | Cinacalcet | Tecalcet Hydrochloride | NPS-2143 | Strontium chloride | Calindol hydrochloride | Poly-D-lysine hydrobromide (MW 30000-70000) | Cinacalcet hydrochloride | AC265347 | Evocalcet | Gadolinium chloride |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 | 臨床前化合物庫 | GPCR靶點分子庫 | 抗代謝疾病化合物庫 | 抗COVID-19化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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