Notoginsenoside R1 NEW
| Price | $63 | $96 | $158 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Notoginsenoside R1 | CAS No.: 80418-24-2 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Notoginsenoside R1 |
| Description | Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties. |
| In vitro | METHODS: Human colorectal cancer cells HCT-116 were treated with Notoginsenoside R1 (75-300 μM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Cell viability of HCT-116 cells treated with 75-300 μM Notoginsenoside R1 was not significantly different from that of the control. However, treatment with 500 μM Notoginsenoside R1 for 48 h resulted in a significant decrease in cell viability (58±7.26%) compared to control cells. [1] METHODS: Human coronary artery smooth muscle cells hCASMC were treated with Notoginsenoside R1 (10 μM) for 24 h. The cells were stimulated with 10% FBS for 0-30 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Akt phosphorylation in hCASMCs was rapidly reduced in a time- and dose-dependent manner after Notoginsenoside R1 treatment, but no effect on ERK1/2 and JNK signaling was observed. notoginsenoside R1 caused a modest reduction in p38 MAPK phosphorylation, but this did not reach significance. [2] |
| In vivo | METHODS: To study the effect on neoplastic endothelial hyperplasia, Notoginsenoside R1 (10 mg/kg) was administered intraperitoneally to C57BL/6 J mice once daily for three weeks. A mouse femoral artery injury model was subsequently performed. RESULTS: Notoginsenoside R1 attenuated neointimal formation after femoral artery injury in vivo.Notoginsenoside R1 treatment reduced neointimal formation by inhibiting VSMC proliferation. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 2.5 mg/mL (2.68 mM) DMSO : 25 mg/mL (26.79 mM) 10% DMSO+90% Saline : 2.5 mg/mL (2.68 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| Keywords | Sanqi glucoside R-1 | I/R | Apoptosis | Inhibitor | anti-apoptosis,cardioprotection | saponin | inhibit | Notoginsenoside R 1 | neuroprotection | Abeta | Notoginsenoside R-1 | Sanqi glucoside R 1 | β-amyloid peptide | Notoginsenoside R1 | Sanchinoside R 1 | Sanchinoside R-1 | anti-inflammatory | Amyloid-β | anti-angiogenic | anti-oxidation |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Saccharide and Glycoside Natural Product Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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