Norverapamil hydrochloride NEW
| Price | $31 | $113 | $197 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Norverapamil hydrochloride | CAS No.: 67812-42-4 |
| Purity: 99.47% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱 | Norverapamil hydrochloride |
| 描述 | Norverapamil hydrochloride (D591 hydrochloride) ((±)-Norverapamil hydrochloride) is an N-demethylated metabolite of Verapamil and it is an L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor. |
| 體外活性 | Norverapamil inhibits macrophage-induced tolerance and attains serum levels comparable to verapamil. Both verapamil and its primary metabolite, Norverapamil, are identified as mechanism-based inhibitors and substrates of CYP3A, exhibiting non-linear pharmacokinetics clinically. Furthermore, ((±)-Norverapamil hydrochloride) proves as effective as verapamil in inhibiting tolerance and killing intracellular M. tuberculosis in monotherapy, matching its efficacy against isoniazid and rifampicin tolerance [1][3]. |
| 體內(nèi)活性 | Norverapamil hydrochloride (9 mg/kg; p.o.) exhibits a terminal half-life of 9.4 hours, an AUC of 260 ng ml?1 h, and a Cmax of 41.6 ng/mL[4]. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 50 mg/mL (104.81 mM) DMSO : 31 mg/mL (64.98 mM) |
| 關(guān)鍵字 | MDR1 | CD243 | Inhibitor | mycobacterial | Norverapamil | M. tuberculosis | Multidrug resistance protein 1 | D 591 Hydrochloride | Ca2+ channels | metabolite | (±)-Norverapamil | P-gp | D-591 Hydrochloride | Calcium Channel | efflux | D591 Hydrochloride | Ca channels | Drug Metabolite | P-glycoprotein | inhibit | Norverapamil Hydrochloride | ABCB1 | Cluster of differentiation 243 | D 591 | Norverapamil hydrochloride | pumps | D-591 | D591 | Pgp |
| 相關(guān)產(chǎn)品 | L-Ascorbic acid | Isonicotinic acid | 1-Octanol |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 疼痛相關(guān)化合物庫 | 膜蛋白靶向化合物庫 | 神經(jīng)保護(hù)化合物庫 | 抑制劑庫 | 抗心血管疾病化合物庫 | 已知活性化合物庫 | 離子通道庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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