NMS-P715 NEW
| Price | $72 | $98 | $155 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: NMS-P715 | CAS No.: 1202055-32-0 |
| Purity: 98.41% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | NMS-P715 |
| 描述 | NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). |
| 體外活性 | NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1]. |
| 體內(nèi)活性 | NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1]. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 2 mg/mL (2.96 mM), Sonication is recommended. |
| 關(guān)鍵字 | NMS-P 715 | Monopolar spindle 1 | Mps1 | NMS P715 | NMS-P-715 | inhibit | NMSP715 | Inhibitor | NMS-P715 |
| 相關(guān)產(chǎn)品 | Sodium lauryl sulfoacetate | TBCA | Vemurafenib | Ellagic acid | CMPD1 | SKLB-163 | Emodin | sodium lauroyl-α-hydroxyethyl sulfonate | LY-364947 | Takinib | NG25 | LY294002 |
| 相關(guān)庫(kù) | 抗結(jié)直腸癌化合物庫(kù) | 成骨分子庫(kù) | PI3K/Akt/mTOR 化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 激酶抑制劑庫(kù) | 抑制劑庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) | 抗癌活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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