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Postion:Product Catalog >NMS-P118
NMS-P118
  • NMS-P118

NMS-P118 NEW

Price $59 $94 $188
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-01

Product Details

Product Name: NMS-P118 CAS No.: 1262417-51-5
Purity: 98.79% Supply Ability: 10g
Release date: 2024/11/01

Product Introduction

Bioactivity

名稱NMS-P118
描述NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.
體外活性NMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 16 mg/mL (40.46 mM), Sonication and heating are recommended.
關(guān)鍵字inhibit | NMS P118 | PARP | NMS-P-118 | NMSP118 | Inhibitor | poly ADP ribose polymerase | NMS-P 118 | NMS-P118
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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