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Postion:Product Catalog >NMS-P118
NMS-P118
  • NMS-P118

NMS-P118 NEW

Price $37 $98 $156
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: NMS-P118 CAS No.: 1262417-51-5
Purity: 98.79% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameNMS-P118
DescriptionNMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.
In vitroNMS-P118 proved to be a potent, orally available, and highly selective PARP-1 inhibitor endowed with excellent ADME and pharmacokinetic profiles and high efficacy in vivo both as a single agent and in combination with Temozolomide in MDA-MB-436 and Capan-1 xenograft models, respectively. Cocrystal structures of 20by with both PARP-1 and PARP-2 catalytic domain proteins allowed rationalization of the observed selectivity.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 16 mg/mL (40.46 mM), Sonication and heating are recommended.
Keywordsinhibit | NMS P118 | PARP | NMS-P-118 | NMSP118 | Inhibitor | poly ADP ribose polymerase | NMS-P 118 | NMS-P118
Inhibitors Related4'-Methoxychalcone | Niraparib tosylate monohyrate | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | 3-Methoxybenzamide | NU1025 | Olaparib | Benzamide | Picolinamide | OUL35
Related Compound LibrariesHighly Selective Inhibitor Library | DNA Damage & Repair Compound Library | Bioactive Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Prostate Cancer Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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