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Postion:Product Catalog >API>Antipyretic analgesics>Nonsteroidal Anti-Inflammatory Drugs (NSAIDS)>Nimesulide
Nimesulide
  • Nimesulide
  • Nimesulide

Nimesulide NEW

Price Get Latest Price
Package 1kg
Min. Order: 1kg
Supply Ability: 20tons
Update Time: 2024-04-11

Product Details

Product Name: Nimesulide CAS No.: 51803-78-2
EC-No.: 257-431-4 Min. Order: 1kg
Purity: 99% Supply Ability: 20tons
Release date: 2024/04/11

Nimesulide properties

Fusing point

140-146°C

Boiling point

442.0 + / - 55.0 ° C (Predicted)

density

1.451 + / - 0.06 g/cm3 (Predicted)

Storage condition

2-8°C

solubility

Almost insoluble in water, easily soluble in acetone, slightly soluble in anhydrous ethanol.

Acidity coefficient

(pKa) pKa6.56 + / - 0.03 (H2O, t = 25, I = 0.02) (Approximate)

colour

Light orange to yellow to green

Water solubility

Solubleinwater(<50&#181; G/ml), 1:10 DMSO: PBS (pH7.2 (< 200 & # 181; g/ml),ethanol(1mg/ml),DMSO

(15mg/ml),DMF(15mg/ml),chloroform,dichloromethane,acetone(freelysoluble),and1NNaOH. Maximum

 wavelength (λmax)391nm(H2O)(lit.)Merck14,6548

stability

It's stable. Incompatible with strong oxidants.

InChIKey:

HYWYRSMBCFDLJT-UHFChemicalbookFFAOYSA-N

EPA Chemical Information:

Methanesulfonamide,N-(4-nitro-2-phenoxyphenyl)-(51803-78-2)




Use and synthesis of Nimesulide

intro

Nimesulide is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects.

 Listed in China in 1997, Nimesulide has been listed in the product dosage forms including tablets, capsules,

 granules, dry suspension, gel. The original approved indications were for the treatment of symptoms such as 

chronic arthritis, pain and inflammation after surgery and acute trauma, and fever due to upper respiratory

 infections.


Pharmacological action

Nimesulide is a non-steroidal anti-inflammatory drug with anti-inflammatory, analgesic and antipyretic effects. 

The mechanism may be related to inhibition of prostaglandin synthesis, leukocyte release and oxidation of 

polymorphonuclear leukocytes.


pharmacokinetics

Oral administration of the drug absorption is rapid and complete, widely in the body and plasma protein binding,

 free drugs only 0.7% to 4.0%. It is mainly distributed in the extracellular fluid, and the metabolites in the liver are 

mainly 4-hydroxyl derivatives, which are excreted from the urine and feces, and the half-life of drug elimination is 

1.96 ~ 4.73h

Article illustration

Company Profile Introduction

Shaanxi TNJONE Pharmaceutical Co., Ltd supplies more than 2,000 kinds of products, covering the whole field of health industry, including human APIs, veterinary APIs, food additives, natural nutrition ingredients, feed additives, cosmetic additives, intermediates etc. With global sourcing advantages, the group is fully capable of meeting the one-stop sourcing needs of global customers. Today, Shaanxi TNJONE Pharmaceutical Co., Ltd.'s marketing network has spread over more than 100 countries and regions on five continents, providing professional service for global customers.

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Shaanxi TNJONE Pharmaceutical Co., Ltd

1YR ChinaChina
  • Since: 2019-05-23
  • Address: No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New C
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