Neurotensin NEW
| Price | $52 | $80 | $162 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Neurotensin | CAS No.: 39379-15-2 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Neurotensin |
| 描述 | Neurotensin is a 13 amino acid neuropeptide that is implicated in the regulation of luteinizing hormone and prolactin release and has significant interaction with the dopaminergic system. |
| 體外活性 | Neurotensin induces the expression of inflammatory markers (MIP-2, MCP-1, IL-1β, TNFα) in murine microglial cells and promotes IL-8 secretion in colon epithelial cells harboring the NTR, a high-affinity receptor belonging to the GPCR family, prevalent in many pancreatic and colorectal cancers. This suggests Neurotensin's potential endocrine role in tumor growth. Acting through NTR1, it activates several signal transduction pathways, including intracellular calcium levels, MAPKs (ERK, JNK), and PKC isoforms. In HCT116 cancer cells, Neurotensin dramatically enhances migration approximately threefold, an effect inhibited by Curcumin pretreatment. Additionally, Neurotensin's activation of the MEK/ERK pathway and subsequent upregulation of AP-1 transcription factors underscore its contribution to cell proliferation. |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 10 mM |
| 關(guān)鍵字 | Inhibitor | Neurotensin Receptor | Neurotensin | inhibit |
| 相關(guān)產(chǎn)品 | SB-657510 | Substance P 1-9 aceate | AF38469 | Meclinertant | Kinetensin acetate(103131-69-7 free base) | SB 611812 | Neurotensin(8-13) 3TFA(60482-95-3(free base)) | (±)-AC 7954 hydrochloride | [Lys8, Lys9]-Neurotensin (8-13) acetate | Urantide acetate(669089-53-6 free base) |
| 相關(guān)庫 | 抗結(jié)直腸癌化合物庫 | 抗胰腺癌化合物庫 | 經(jīng)典已知活性庫 | 多肽分子庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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