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Postion:Product Catalog >Netupitan
Netupitan
  • Netupitan
  • Netupitan

Netupitan NEW

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Package 10G 100G 1000G
Min. Order: 10G
Supply Ability: 10KG
Update Time: 2024-11-07

Product Details

Product Name: Netupitan CAS No.: 290297-26-6
Min. Order: 10G Purity: 99%
Supply Ability: 10KG Release date: 2024/11/07

It appears there might be a typographical error in your query. You may be referring to **Netupitant**, a pharmaceutical compound commonly used in the prevention of chemotherapy-induced nausea and vomiting (CINV). Below is a comprehensive overview of Netupitant, its applications, and relevant information.


## **Netupitant Overview**


**Netupitant** is an NK? (neurokinin-1) receptor antagonist. It is primarily used in combination with other antiemetic agents to prevent nausea and vomiting associated with highly emetogenic chemotherapy. The combination product containing Netupitant and Palonosetron is marketed under the brand name **Akynzeo**.


## **Applications of Netupitant**


### 1. **Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV)**

Netupitant is most notably used to prevent both acute and delayed phases of CINV in patients undergoing cancer chemotherapy. Its effectiveness in this role makes it a valuable component of antiemetic regimens.


- **Acute Phase CINV:** Occurs within the first 24 hours after chemotherapy.

- **Delayed Phase CINV:** Occurs after 24 hours and can last up to several days.


### 2. **Combination Therapy with Palonosetron**

Netupitant is often combined with **Palonosetron**, a 5-HT? receptor antagonist, to enhance antiemetic efficacy. This combination targets multiple pathways involved in the emetic response, providing comprehensive protection against nausea and vomiting.


- **Brand Name:** Akynzeo

- **Mechanism:** While Netupitant blocks the NK? receptors, Palonosetron inhibits the 5-HT? receptors, together providing a synergistic effect.


### 3. **Potential Use in Radiation-Induced Nausea and Vomiting**

Although primarily approved for CINV, there is ongoing research into the efficacy of Netupitant in managing nausea and vomiting induced by radiation therapy.


### 4. **Exploration in Other Therapeutic Areas**

Research is being conducted to explore the potential benefits of NK? receptor antagonists like Netupitant in treating other conditions characterized by excessive vomiting, such as:


- **Postoperative Nausea and Vomiting (PONV):** Managing nausea and vomiting after surgery.

- **Pregnancy-Related Nausea:** Investigating safety and efficacy in pregnant populations, though currently not a standard treatment.


## **Mechanism of Action**


Netupitant works by selectively blocking the NK? receptors in the central nervous system. Substance P, a neuropeptide, binds to these receptors and plays a significant role in inducing vomiting. By inhibiting this interaction, Netupitant effectively reduces the likelihood of nausea and vomiting.


## **Dosage and Administration**


Netupitant is administered orally, typically as part of the combination product with Palonosetron. The standard regimen involves taking one capsule approximately one hour before chemotherapy sessions. The exact dosage and duration should be determined by a healthcare professional based on individual patient needs and chemotherapy protocols.


## **Safety and Side Effects**


While Netupitant is generally well-tolerated, some potential side effects include:


- **Common Side Effects:**

  - Fatigue

  - Headache

  - Dizziness

  - Constipation


- **Serious Side Effects:**

  - Allergic reactions (rare)

  - Changes in liver function tests (monitoring may be required)


**Contraindications:**

- Hypersensitivity to Netupitant or any component of the formulation.

- Use with certain medications that may interact adversely, such as strong CYP3A4 inhibitors.


**Precautions:**

- Patients with liver impairment may require dosage adjustments.

- Caution in patients with a history of cardiovascular disorders.


## **Conclusion**


Netupitant is a crucial component in the management of chemotherapy-induced nausea and vomiting, significantly improving the quality of life for cancer patients undergoing treatment. Its use in combination with Palonosetron provides a robust antiemetic strategy by targeting multiple pathways involved in the emetic response. Ongoing research may further expand its applications into other areas where nausea and vomiting are prevalent symptoms.


If you were referring to a different compound or product named "Netupitan," please provide additional context or verify the spelling so I can offer more accurate information.


Company Profile Introduction

Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance. With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy. At Watson Biotechnology, we pride ourselves on our cutting-edge facilities and state-of-the-art technology, which enable us to deliver superior products that cater to a diverse range of needs across various sectors. Our dedication to continuous improvement and customer satisfaction drives us to maintain stringent quality control processes and foster an environment of innovation and growth. Join us at Watson Biotechnology Co., Ltd as we continue to pioneer advancements in biotechnology and contribute to a healthier, more sustainable future.

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