Neomycin sulfate NEW
| Price | $50 |
| Package | 10g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Neomycin sulfate | CAS No.: 1405-10-3 |
| Purity: 99.87% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Neomycin sulfate |
| Description | Neomycin sulfate (Framycin sulfate) is a broad-spectrum aminoglycoside antibiotic that blocks the synthesis of bacterial proteins in order to exert antimicrobial activity. Neomycin sulfate is commonly used to screen prokaryotic and eukaryotic cells for Neo resistance genes. |
| In vitro | METHODS: BHK-21 cells, VERO cells and FEA cells were treated with Neomycin sulfate (1000-20000 μg/mL) for 24 h. Cell viability was measured by MTT. RESULTS: The viability of BHK-21 cells was significantly reduced by 9000-20000 μg/mL Neomycin treatment. 3000 μg/mL Neomycin treatment significantly reduced the viability of FEA cells. 20000 μg/mL Neomycin treatment did not affect the viability of VERO cells. [1] METHODS: Mouse cochlear hair cells HEI-OC-1 were treated with Neomycin sulfate (2 mM) for 24 h. Apoptosis was detected by Flow Cytometry. RESULTS: 20 μM GM1 significantly reduced Neomycin sulfate-induced cell death in HEI-OC-1 cells. [2] |
| In vivo | METHODS: To assay in vivo activity, Neomycin sulfate (20 mg/mouse) and bacitracin (20 mg/mouse) were administered by gavage to C57BL/10 mice once daily for seven days. RESULTS: The combination of Neomycin and bacitracin decreased intestinal permeability and increased gene expression of ZO-1, JAM-A, and occludin in the ileum and ZO-1, claudin-3, and claudin-4 in the colon. [3] METHODS: To deplete the intestinal microbiota of mice, the antibiotics (ABX) vancomycin (0.5 g/L), ampicillin (1 g/L), Neomycin sulfate (1 g/L), and metronidazole (1 g/L) were administered to mice by drinking water for two weeks. RESULTS: Antibiotics significantly reduced the diversity and composition of the gut microbiota. [4] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : Insoluble H2O : 10 mM |
| Keywords | Framycin Sulfate | Phospholipase | ribosomal | protein | Inhibitor | proliferation | Antibiotic | aminoglycoside | Neomycin sulfate | angiogenin | Neomycin | synthesis | Bacterial | Neomycin Sulfate | inhibit |
| Related Compound Libraries | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Drug Repurposing Compound Library | Natural Product Library | Microbial Natural Product Library | Natural Product Library for HTS | FDA-Approved Drug Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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