Nabumetone NEW
| Price | $45 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-05 |
Product Details
| Product Name: Nabumetone | CAS No.: 42924-53-8 |
| Purity: 99.61% | Supply Ability: 10g |
| Release date: 2024/11/05 |
Product Introduction
Bioactivity
| 名稱 | Nabumetone |
| 描述 | Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II. |
| 激酶實驗 | Cells are harvested, washed, and lysed in NP-40 lysis buffer (50 mM Tris-HCl [pH 7.5], 150 mM NaCl, 0.5% NP-40). Total cell protein is quantified using the Bradford assay and 1-mg/mL protein aliquots are made. Ten microliters of total cell protein is mixed with 290 μL of substrate solution (0.1 mg/mL dithiothreitol [DTT], 0.1 mg/mL albumin, and 1 mM alanine-β-naphthylamide). Fluorometric measurements (340 nm excitation, 400 nm emission) are made after 15 and 30 min. The slope of the line between the 15- and 30-min measurements is used to represent aminopeptidase activity. Total cell protein is preincubated with bestatin, amastatin, puromycin, EDTA, and/or ZnCl2 for 20 min before the fluorometric aminopeptidase assay. |
| 體外活性 | Nabumetone exhibits anti-inflammatory activity in rat models of carrageenan-induced edema and UV-induced erythema in guinea pigs. In a rat granuloma model, Nabumetone is non-toxic at concentrations higher than the minimum effective dose. Furthermore, in adjuvant-induced arthritic rats, Nabumetone demonstrates good gastric tolerability at doses exceeding those required for anti-inflammatory efficacy. |
| 體內(nèi)活性 | Nabumetone undergoes extensive first-pass metabolism to form its main active metabolite (6-MNA) in the systemic circulation, which is capable of inhibiting COX-2. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (240.92 mM) Ethanol : 24 mg/mL (105.1 mM) |
| 關(guān)鍵字 | Cyclooxygenase | Inhibitor | COX | inhibit | BRL 14777 | BRL-14777 | Nabumetone |
| 相關(guān)產(chǎn)品 | Ibuprofen | Acetaminophen | Paradol | Melatonin |
| 相關(guān)庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | 抑制劑庫 | 抗癌上市藥物庫 | FDA 上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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