Mycophenolate Mofetil NEW
| Price | $47 | $63 | $98 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Mycophenolate Mofetil | CAS No.: 128794-94-5 |
| Purity: 99.11% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名稱(chēng) | Mycophenolate Mofetil |
| 描述 | Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH). |
| 體外活性 | As an ester prodrug of the active immunosuppressant mycophenolic acid, Mycophenolate mofetil (10 μg/mL) significantly induces apoptosis in microglial cell cultures and increases the number of apoptotic cells due to activated caspase-3 immunoreactivity. At a concentration of 1 μg/mL, Mycophenolate mofetil also potently inhibits the proliferation of astrocytes and microglia. Recent studies have shown that following neuronal injury, Mycophenolate mofetil significantly reduces the extent of neuronal cell death in organotypic hippocampal slice cultures in a time-dependent manner. Mycophenolic acid inhibits the activity of both type I/II isocitrate dehydrogenase in a non-competitive, reversible, and selective manner, with IC50 values of 39 nM and 27 nM, respectively. Moreover, it concentration-dependently inhibits the proliferation of ConA-stimulated T cells (IC50 = 100 nM), lipopolysaccharide-stimulated B cells (IC50 = 120 nM), and alloantigen-specific T cell proliferation (IC50 = 51 nM). |
| 體內(nèi)活性 | At a high concentration of 10 μg/mL, Mycophenolate mofetil induces significant apoptosis in microglial cell cultures and increases the number of apoptotic cells exhibiting elevated levels of activated caspase-3 immunoreactivity. Furthermore, at 1 μg/mL, it strongly inhibits the proliferation of microglia and astrocytes. Recent studies have demonstrated that Mycophenolate mofetil significantly attenuates the extent of neuronal death in organotypic hippocampal slice cultures following neuronal injury in a time-dependent manner. Mycophenolate mofetil, an active immunosuppressive ester prodrug of mycophenolic acid, exhibits non-competitive, selective, and reversible inhibition of inosine monophosphate dehydrogenase type I/II, with IC50 values of 39 nM and 27 nM, respectively. Moreover, mycophenolic acid, the immunosuppressive agent, also inhibits the proliferation of T cells stimulated by ConA, B cells stimulated by lipopolysaccharide, and allospecific T cells in a concentration-dependent manner, with IC50 of 100 nM, 120 nM, and 51 nM, respectively. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 18.33 mg/mL (42.29 mM), Sonication is recommended. |
| 關(guān)鍵字 | Inhibitor | Apoptosis | RS-61443 | Mycophenolate Mofetil | inhibit | Drug Metabolite | RS61443 |
| 相關(guān)庫(kù) | 經(jīng)典已知活性庫(kù) | EMA 上市藥物庫(kù) | 抗病毒庫(kù) | 藥物功能重定位化合物庫(kù) | 抑制劑庫(kù) | 微生物天然產(chǎn)物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 抗癌上市藥物庫(kù) | 已知活性化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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