Product Details
| Product Name:
Mps1-IN-5 |
CAS No.:
2890819-31-3 |
| Supply Ability:
10g |
Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Mps1-IN-5 |
| Description | Mps1-IN-5 is a potent, orally active Mps1 inhibitor exhibiting an IC50 of 29 nM, known for triggering apoptosis and G2/M phase cell cycle arrest. This compound demonstrates antiproliferative and anti-tumor effects by inhibiting Mps1 phosphorylation and inducing DNA damage [1]. |
| In vitro | Mps1-IN-5 (compound 12) inhibited the proliferation of MCF-7 and 4T1 cells in a time-dependent manner at 0-10 μM over 24, 48, and 72 hours [1]. It induced apoptosis and caused G2/M phase cell cycle arrest in a dose-dependent manner at 0, 0.5, 1.0, and 5.0 μM for 24 and 48 hours [1]. Additionally, at 0, 0.03, 0.1, 1, or 3 μM for 2 hours, the compound inhibited Mps1 phosphorylation and induced DNA damage [1]. |
| In vivo | Mps1-IN-5 (30, 60 mg/kg; oral administration; daily for 15 days) effectively suppresses tumor growth in a breast cancer model without significant toxicity [1]. |
| Storage | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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