MPP+ iodide NEW
| Price | $33 | $46 | $75 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-18 |
Product Details
| Product Name: MPP+ iodide | CAS No.: 36913-39-0 |
| Purity: 99.96% | Supply Ability: 10g |
| Release date: 2024/11/18 |
Product Introduction
Bioactivity
| Name | MPP+ iodide |
| Description | MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells. |
| In vitro | METHODS: Human neuroblastoma cells SH-SY5Y were treated with MPP+ iodide (1-4 mM) for 12-48 h, and cell viability was detected using CCK-8 Assay. |
| In vivo | METHODS: To test for acute toxicity to embryonic or neonatal mice, MPP+ iodide (8.6-34.2 mg/kg) was injected intraperitoneally into pregnant or neonatal mice. RESULTS: Neurotoxicity induced by a single injection of MPP+ iodide was transient and recoverable in embryonic and neonatal mice. In contrast, no significant changes in MAO-A and MAO-B expression levels were observed in MPP+ iodide-treated mice. [3] |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 100 mg/mL (336.54 mM), Sonication is recommended. DMSO : 50 mg/mL (168.28 mM), Sonication is recommended. |
| Keywords | MPP+ | Mitochondrial Metabolism | dopaminergic | neurons | MPP+ iodide | respiratory | chain | Inhibitor | inhibit | neurotoxic | MPP+ Iodide | complex |
| Inhibitors Related | Stavudine | Xylitol | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Curcumin | Oxyresveratrol | Paeonol | Naringin | Salicylic acid | Gefitinib |
| Related Compound Libraries | 銅死亡化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 自噬庫(kù) | NO PAINS 化合物庫(kù) | 代謝化合物庫(kù) | 抗衰老化合物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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