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MLS1547 NEW

Price	$35	$52	Get Latest Price
Package	10mg	25mg	50mg

Min. Order:
Supply Ability:	10g
Update Time:	2024-11-19

Product Details

Product Name: MLS1547	CAS No.: 315698-36-3
Purity: 98.02%	Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

Name	MLS1547
Description	MLS1547 (MLS000051547) is a highly efficacious agonist of G protein-biased dopamine D2 receptor with a Ki of 1.2 μM. MLS1547 stimulates D2R G protein-mediated signaling with EC50 of 0.37 μM in a calcium mobilization assay.
In vitro	MLS1547 fully antagonizes dopamine-mediated β-arrestin recruitment to the D2 dopamine receptor, with an IC50 of 9.9 μM in the DiscoveRx assay and 3.8 μM in the BRET assay, and completely displaces [3H]methylspiperone binding to the D2 dopamine receptor, with a Ki of 1.2 μM[2].
Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 45 mg/mL (126.82 mM)
Keywords	MLS-000051547 \| Inhibitor \| inhibit \| biased \| β-arrestin \| MLS1547 \| Dopamine Receptor \| MLS 000051547 \| protein \| signaling \| recruitment
Inhibitors Related	Olanzapine \| CLOZAPINE N-OXIDE \| Mirtazapine \| Promazine hydrochloride \| Octopamine hydrochloride \| Octodrine \| Citicoline \| Phenothiazine \| Oxolinic acid \| Mianserin hydrochloride \| Doxepin hydrochloride \| Fluphenazine dihydrochloride
Related Compound Libraries	Bioactive Compound Library \| Anti-Neurodegenerative Disease Compound Library \| Antidepressant Compound Library \| Neuronal Signaling Compound Library \| Membrane Protein-targeted Compound Library \| Neurotransmitter Receptor Compound Library \| Bioactive Compounds Library Max \| GPCR Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.