ML-210 NEW
| Price | $34 | $48 | $79 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-07 |
Product Details
| Product Name: ML-210 | CAS No.: 1360705-96-9 |
| Purity: 97% | Supply Ability: 10g |
| Release date: 2024/11/07 |
Product Introduction
Bioactivity
| 名稱 | ML-210 |
| 描述 | ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis. |
| 體外活性 | METHODS: Human lung adenocarcinoma cell line HCC4006 was treated with ML-210 (10 μM) for 1 h. CETSA profiles were detected by Western Blot. RESULTS: ML-210 affects the thermal stability of GPX4, consistent with the binding to the cellular target. [1] METHODS: DRD cell lines were treated with ML-210 for 48 h, and cell viability was measured. RESULTS: ML-210 has an IC50 of 107 nM in the DRD cell line. [2] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 11 mg/mL (23.14 mM) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1.1 mg/mL (2.31 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| 關(guān)鍵字 | residue | Ferroptosis | inhibit | peroxidase | ML210 | Covalent | selenocysteine | Glutathione Peroxidase | glutathione | CID-49766530 | Inhibitor | CID49766530 | ML-210 | ML 210 | GPX4 | anti-cancer |
| 相關(guān)產(chǎn)品 | TBHQ | Acetylcysteine | Butylated hydroxytoluene | α-Vitamin E | Sorafenib | Curcumin | Artemisinin | L-Cystine | L-Glutamic acid monosodium salt | Coenzyme Q10 | 5-Aminosalicylic Acid | Melatonin |
| 相關(guān)庫 | 疼痛相關(guān)化合物庫 | 經(jīng)典已知活性庫 | 膜蛋白靶向化合物庫 | 激酶抑制劑庫 | 抗肥胖化合物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | GPCR靶點分子庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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