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Postion:Product Catalog >ML-193
ML-193
  • ML-193

ML-193 NEW

Price $39 $67 $112
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-14

Product Details

Product Name: ML-193 CAS No.: 713121-80-3
Purity: 97.74% Supply Ability: 10g
Release date: 2024/11/14

Product Introduction

Bioactivity

名稱ML-193
描述ML-193 (CID 1261822) is a potent and selective GPR55 antagonist (IC50: 221 nM) with over 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It can ameliorate motor and sensorimotor deficits in Parkinson’s disease (PD) rats.
體外活性ML193, a selective GPR55 antagonist.?ML184 significantly promoted neuronal differentiation in vitro while ML193 reduced differentiation rates as compared to vehicle treatment.Continuous administration of O-1602 into the hippocampus via a cannula connected to an osmotic pump resulted in increased Ki67+ cells within the dentate gyrus.?O-1602 increased immature neuron generation, as assessed by DCX+ and BrdU+ cells, as compared to vehicle-treated animals.?GPR55-/- animals displayed reduced rates of proliferation and neurogenesis within the hippocampus while O-1602 had no effect as compared to vehicle controls[2].
體內(nèi)活性Intra-striatal administration of ML193 increased time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats mostly at the dose of 1 g/rat[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 60 mg/ml (113.72 mM)
關(guān)鍵字Inhibitor | deficits | motor | ML193 | ML-193 | sensorimotor | ML 193 | G protein-coupled receptor 55 | disease | Parkinson | CID1261822 | CID-1261822 | inhibit | GPR55
相關(guān)產(chǎn)品β-Caryophyllene | Pregnenolone acetate | 2,3-Butanediol
相關(guān)庫經(jīng)典已知活性庫 | 神經(jīng)信號(hào)分子庫 | 膜蛋白靶向化合物庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫 | GPCR靶點(diǎn)分子庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Recommended supplier

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Xiamen Wonderful Bio Technology Co., Ltd.
2023-07-21
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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