Mizoribine NEW
| Price | $45 | $61 | $97 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Mizoribine | CAS No.: 50924-49-7 |
| Purity: 99.98% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名稱 | Mizoribine |
| 描述 | Mizoribine (NSC-289637) belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis. |
| 體外活性 | Mizoribine selectively inhibits guanine ribonucleotide synthesis in purified T-cells, while the mechanism of 6-thioguanine (6MP) appears to rely more on the depletion of adenine ribonucleotides. In a dose-dependent manner, Mizoribine at 1-50 mg/mL suppresses T-cell proliferation induced by all tested stimuli by 10-100%. This suppression is reversible with the addition of guanosine to replenish the guanine nucleotide pool when 50 mM is incorporated. Furthermore, Mizoribine impedes HCV RNA replication with an IC50 of 100 μM and causes a reduction in intracellular GTP levels, with GTP supplementation reversing its antiproliferative effect. |
| 體內(nèi)活性 | Administration of 5 or 10 mg/kg Mizoribine resulted in increased expression of MCP-1, OPN, and TGF-β1 mRNA in untreated OLETF rats. Simultaneously, this dose of Mizoribine inhibited urinary albumin excretion and attenuated the progression of glomerulosclerosis, renal interstitial fibrosis, and macrophage infiltration in the rat kidneys. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (231.46 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : 47 mg/mL (181.3 mM) |
| 關(guān)鍵字 | Immunosuppressant | SARS-CoV | Mizoribine | IMPDH | NSC289637 | nucleoside | Hepatitis C virus | HE-69 | HCV | SARS coronavirus | NSC-289637 | Inhibitor | inhibit | HE69 |
| 相關(guān)產(chǎn)品 | Kojic acid | Methyl 2-amino-5-bromobenzoate | Remdesivir | Ribavirin | Silymarin | Hydroxychloroquine | Chloroquine phosphate | Oxyresveratrol | Artemisinin | 2-Ketoglutaric acid | Dexamethasone | Methyl cinnamate |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 經(jīng)典已知活性庫(kù) | 天然產(chǎn)物庫(kù) | 藥物功能重定位化合物庫(kù) | 抗病毒庫(kù) | 抗感染天然產(chǎn)物庫(kù) | 已知活性化合物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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