Minocycline hydrochloride NEW
| Price | $38 | $50 | $62 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-04 |
Product Details
| Product Name: Minocycline hydrochloride | CAS No.: 13614-98-7 |
| Purity: 99.89% | Supply Ability: 10g |
| Release date: 2024/11/04 |
Product Introduction
Bioactivity
| 名稱 | Minocycline hydrochloride |
| 描述 | Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment. |
| 體外活性 | Minocycline exhibits significant neuroprotective effects in models of cerebral ischemia, traumatic brain injury, Huntington's disease, and Parkinson's disease. Its neuroprotective properties may involve the inhibition of 5-lipoxygenase (an inflammatory enzyme associated with brain aging). Additionally, Minocycline's activity is linked to the inhibition of protein synthesis. |
| 體內(nèi)活性 | Minocycline inhibits the release of cytochrome c mediated by the permeability transition in mitochondria. This inhibition by minocycline on cytochrome c release has been demonstrated in vivo, in cells, and isolated mitochondria. Additionally, minocycline suppresses the activity of inducible caspase-1 and caspase-3, inducible nitric oxide synthase (iNOS), and p38 mitogen-activated protein kinase (MAPK). Following experimental focal ischemia, minocycline reduces the upregulation of caspase-1 and iNOS, thereby decreasing infarct size. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 12.4 mg/mL (25 mM) DMSO : 60 mg/mL (121.47 mM) |
| 關(guān)鍵字 | Antibiotic | Calcium Channel | Inhibitor | HIF-PH | Myocardial ischemia | MDM-2/p53 | PI3K/Akt | Apoptosis | Potassium Channel | inhibit | Ca2+ channels | Hypoxia-inducible factors | HIFs | infection | L-type Ca2+ channel | Minocycline hydrochloride | stroke | cerebral ischemia | HIF/HIF Prolyl-Hydroxylase | Ca channels | acinetobacter | neuroprotective | Minocycline | Minocycline Hydrochloride | KcsA | ovarian cancer | Mitochondrial ATP-sensitive potassium | Ventricular arrhythmia | Bacterial |
| 相關(guān)產(chǎn)品 | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Methyl anthranilate | Kanamycin sulfate | Sulfamethoxazole sodium | Metronidazole | Doxycycline | Hydroxycitric acid tripotassium hydrate | EDTA copper(II) disodium salt | Dimethyl sulfoxide | Crystal Violet |
| 相關(guān)庫 | 經(jīng)典已知活性庫 | 上市藥物庫 | 藥物功能重定位化合物庫 | 神經(jīng)保護化合物庫 | FDA 上市藥物庫 | 口服活性化合物庫 | 臨床期小分子藥物庫 | 已知活性化合物庫 | 抗COVID-19化合物庫 | 抗感染化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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