Milnacipran hydrochloride NEW
| Price | $31 | $56 | $81 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Milnacipran hydrochloride | CAS No.: 101152-94-7 |
| Purity: 98% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Milnacipran hydrochloride |
| Description | Milnacipran hydrochloride (Savella) is a serotonin and norepinephrine reuptake inhibitor used to treat major depressive disorders. Milnacipran hydrochloride is an enantiomer of milnacipran, which is used to treat fibromyalgia. Milnacipran hydrochloride and milnacipran have been associated with a low rate of transient elevations in serum aminotransferase levels during treatment and with rare instances of clinically apparent acute liver injury with jaundice. |
| In vitro | In rat prefrontal cortex, Milnacipran (10 and 30 mg/kg, p.o.) was found to dose-dependently increase extracellular levels of NA and 5-HT. In antidepressant animal behavioral models, Milnacipran (30 and 60 mg/kg, p.o.) significantly reduced immobility time in the forced swim test in rats. Similarly, in animal models of anxiety, Milnacipran (30 and 60 mg/kg, p.o.) notably decreased immobility time in the conditioned fear stress test. In freely moving guinea pigs' hypothalamus, treatment with Milnacipran (10 mg/kg and 40 mg/kg) resulted in a 57% and 47% reduction in the NA metabolite MHPG respectively. Furthermore, Milnacipran (<40 mg/kg, i.p.) increased extracellular levels of NA and 5-HT in the hypothalamus of freely moving guinea pigs in a dose-dependent manner. |
| In vivo | Over 80% of Milnacipran is excreted in the urine primarily in its unchanged form and as glucuronide conjugates, with less than 10% metabolized through CYP3A4 enzyme-mediated N-deethylation. At high concentrations, Milnacipran can inhibit certain ligand-gated ion channel receptors, including 5-HT3A (IC50: 185 μM), NMDA (IC50: 58.4 μM), and nACh (IC50: 14.3 μM) receptors. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 28.3 mg/mL (100 mM) DMSO : 50 mg/mL (176.8 mM), Sonication is recommended. |
| Keywords | Milnacipran hydrochloride | 5-HTT | inhibit | Serotonin Transporter | SLC6A4 | Milnacipran | Inhibitor | Milnacipran Hydrochloride | SERT |
| Inhibitors Related | Nortriptyline hydrochloride | Dapoxetine hydrochloride | Diosmin | Fluvoxamine maleate | Amitriptyline hydrochloride | Vortioxetine hydrobromide | Fluoxetine hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Drug-Fragment Library | CNS-Penetrant Compound Library | Inhibitor Library | NO PAINS Compound Library | FDA-Approved Drug Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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