Mianserin hydrochloride NEW
| Price | $30 | $35 | $108 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Mianserin hydrochloride | CAS No.: 21535-47-7 |
| Purity: 99.82% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱(chēng) | Mianserin hydrochloride |
| 描述 | Mianserin hydrochloride (Org GB 94) is a tetracyclic compound with antidepressant properties that blocks alpha-adrenergic, histamine H1, and certain serotonin receptors; it may cause drowsiness and hematological issues. |
| 體外活性 | Mianserin dose-dependently elevates extracellular norepinephrine levels in the prefrontal cortex with minimal impact on the reuptake of norepinephrine in the rat cerebral cortex, due to its blockade of presynaptic inhibitory α2-adrenergic receptors and induction of regeneration-mediated release enhancement. In neonatal 6-OHDA-lesioned rats, mianserin attenuates the effects of SKF38393 and M-CPP, indicating that the actions of dopamine receptor agonists are mediated through the 5-HT neurochemical system. Additionally, in the medial prefrontal cortex of neonatal 6-OHDA-lesioned rats, 10 mg/kg S.C. Mianserin increased extracellular dopamine approximately 6-fold. |
| 體內(nèi)活性 | In elevated plus-maze experiments, Eltoprazine and Mianserin exhibit opposite effects: Eltoprazine induces anxiogenic-like behavior, while Mianserin triggers an anxiolytic-like response. Mianserin leads to a decreased number of these sites, whereas Eltoprazine results in an increase. Additionally, a subcutaneous dose of 2 mg/kg Mianserin produces a significant statistical increase in dopamine levels, exceeding 30% when compared to saline. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | H2O : 99.7 mM DMSO : 4.23 mg/mL (14.06 mM), Sonication is recommended. |
| 關(guān)鍵字 | Org GB94 | Mianserin hydrochloride | Inhibitor | inhibit | Mianserin Hydrochloride | Histamine Receptor | Org GB-94 | Mianserin |
| 相關(guān)產(chǎn)品 | Alverine citrate | Dapoxetine hydrochloride | Meclizine dihydrochloride | Lidocaine | Famotidine | Octopamine hydrochloride | Oxolinic acid | Alginic acid | Trazodone hydrochloride |
| 相關(guān)庫(kù) | 疼痛相關(guān)化合物庫(kù) | 經(jīng)典已知活性庫(kù) | 神經(jīng)退行性疾病化合物庫(kù) | 膜蛋白靶向化合物庫(kù) | 抗癌臨床化合物庫(kù) | 藥物功能重定位化合物庫(kù) | 抗癌上市藥物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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