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Postion:Product Catalog >MI-2-2
MI-2-2
  • MI-2-2

MI-2-2 NEW

Price $58 Get Latest Price
Package 1mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: MI-2-2 CAS No.: 1454920-20-7
Purity: 99.56% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameMI-2-2
DescriptionMI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
In vitroMI-2-2 inhibits the bivalent fragment of MLL, consisting of MBM1 and MBM2, with an IC50 of 520 nM. It effectively suppresses cell proliferation, differentiation, and Hoxa9 expression. Additionally, MI-2-2 shows significant activity at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1].
Storagekeep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : Soluble
Keywordscell proliferation | inhibit | menin-MLL interaction | MI 22 | Epigenetic Reader Domain | MI-2-2 | Inhibitor | MI-22 | Hoxa9 expression | differentiation | leukemia
Inhibitors RelatedBIX-01294 trihydrochloride | Tazemetostat | Piribedil | XY1 | UNC 0631 | GSK126 | MAK683 | EZM 2302 | EPZ015666 | AMI-1 free acid | MS37452 | MRTX-1719
Related Compound LibrariesBioactive Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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