Mevastatin NEW
| Price | $51 | $77 | $223 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-08 |
Product Details
| Product Name: Mevastatin | CAS No.: 73573-88-3 |
| Purity: 97.96% | Supply Ability: 10g |
| Release date: 2024/11/08 |
Product Introduction
Bioactivity
| 名稱 | Mevastatin |
| 描述 | Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum. Mevastatin was the first statin to enter clinical trials. |
| 體外活性 | Mevastatin competitively inhibits HMG-CoA reductase, subsequently reducing cholesterol synthesis in the liver. After 14 days of high-dose treatment, a more than 30% increase in baseline absolute cerebral blood flow was observed. Oral administration of Mevastatin at doses of 5 mg/kg and 20 mg/kg led to reductions in serum cholesterol levels 3 hours post-administration, with the 20 mg/kg dosage decreasing serum cholesterol by approximately 30%. |
| 體內活性 | The bicyclic portion of Mevastatin binds to the active site of coenzyme A. Mevastatin elevates eNOS mRNA and protein levels, reduces infarct size, and ameliorates neurological deficits in a dose- and time-dependent manner. At a concentration of 0.01 pg/mL (26 nM), Mevastatin can reduce cholesterol synthesis by 50% compared with the control group. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (128.04 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關鍵字 | BMP-2 | cardiovascular | Apoptosis | inhibit | phosphorylation | lipid-lowering | neuroprotection | EGFR | NF-κB | Statins | Antibiotic | Autophagy | Bacterial | RANKL | HMG-CoA Reductase (HMGCR) | eNOS | Mevastatin | Inhibitor |
| 相關產品 | Neomycin sulfate | Sulfamethoxazole sodium | Hydroxychloroquine | Guanidine hydrochloride | Doxycycline | Tributyrin | Dimethyl sulfoxide |
| 相關庫 | 抗癌天然產物庫 | 萜類天然產物庫 | 經典已知活性庫 | 天然產物庫 | 微生物天然產物庫 | 抑制劑庫 | 高通量篩選天然產物庫 | 抗衰老化合物庫 | 抗感染天然產物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $77.00/100mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-08 | |
| $10.00/1KG |
VIP6Y
|
Hebei Weibang Biotechnology Co., Ltd
|
2024-11-05 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mojin Biotechnology Co., Ltd
|
2023-09-06 | |
| $0.00/10g |
VIP2Y
|
Hangzhou ICH Biofarm Co., Ltd
|
2023-07-04 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-10 | ||
| $0.00/1KG |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2020-05-11 | |
| $6.00/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-03-09 | |
| $1.00/25Kg/Drum |
HubeiwidelychemicaltechnologyCo.,Ltd
|
2019-10-29 | ||
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
|
2021-07-09 |
United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
INQUIRY