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Use of Methyldopa

Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.Target: alpha-adrenergic agonistMethyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (also known as pregnancy-induced hypertension (PIH)).Methyldopa has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, also known as aromatic L-amino acid decarboxylase, which converts L-DOPA into dopamine. Dopamine is a precursor for norepinephrine (noradrenaline) and subsequently epinephrine (adrenaline). This inhibition results in reduced dopaminergic and adrenergic neurotransmission in the peripheral nervous system. This effect may lower blood pressure and cause central nervous system effects such as depression, anxiety, apathy, anhedonia, and parkinsonism. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase (DBH). α-methylnorepinephrine is an agonist of presynaptic central nervous system α2-adrenergic receptors. Activation of these receptors in the brainstem appears to inhibit sympathetic nervous system output and lower blood pressure. This is also the mechanism of action of clonidine.

FAQ:

1: Can I have a sample order for your products?

Yes, we can supply the free sample, but the shipping cost be paid by our customers.

2: How to confirm the Product Quality before placing orders?

1) You can get free samples for some products, just pay the basic cost for us.

2) Also you can send the specification or your request to us, we will customize the products for you.

3: How do you deal with quality complaints?

A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by us, we will send you free goods for replacement or refund.

4: Can you give me a discount?

A: Of course, it depends on your quantity.

5:Are you a trading company or a manufacturer?

We are both, so we can always provide wholesale price and most products in stock.

6:How to contact us?

You can chat with us by Whatsapp ,Telegram,& Wickr me Online.

You can choose your interested products and send inquiry to us.

You can send Email to us, you will get our reply.

7: Which kind of payment do you accept?

 T/T,Paypal,Visa,L/C,Western Union,or according to your needs.

8: Package

We have standard package, or it can be customized as per your request.

9: Transportation

UPS,TNT,EMS,Fedex,and so on.According to your location, safe customs clearance, generally delivered to your door within7 -15 days in Europe and the United States.