Methyl-β-cyclodextrin NEW
| Price | $33 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-12 |
Product Details
| Product Name: Methyl-β-cyclodextrin | CAS No.: 128446-36-6 |
| Purity: ≥98% | Supply Ability: 10g |
| Release date: 2024/11/12 |
Product Introduction
Bioactivity
| 名稱 | Methyl-β-cyclodextrin |
| 描述 | Methyl-β-cyclodextrin (Methyl-beta-cyclodextrin) is a macrocyclic compound utilized as a solubilizer for hydrophobic substances in biological studies, and serves as a lipid raft inhibitor with cholesterol-lowering and potential antitumor activities. |
| 細(xì)胞實(shí)驗(yàn) | PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined[1]. |
| 激酶實(shí)驗(yàn) | PEL cells are incubated in triplicate in a 96-well microculture plate in the presence of different concentrations of methyl-β-cyclodextrin (0-10 mM) in a final volume of 0.1 mL for 24 h at 37°C. Subsequently, MTT (0.5 mg/mL final concentration) is added to each well. After 3 h of additional incubation, 100 μL of a 0.04 N HCl is added to dissolve the crystals. Absorption values at 570 nm are determined. |
| 體外活性 | METHODS: Five primary exudative lymphoma (PEL) cell lines, BCBL-1, BC-1, BC-3, TY-1, and GTO, were treated with Methyl-β-cyclodextrin (0-10 mM) for 24 h, and cell viability was measured by MTT assay. RESULTS: Methyl-β-cyclodextrin dose-dependently inhibited the growth of PEL cells with IC50 between 3.33-4.23 mM. [1] METHODS: Chicken hepatocellular carcinoma cells, LMH, were treated with Methyl-β-cyclodextrin (10 mM) for 1 h, then cholesterol (50 μg/mL) was added at different time points before, during, and after infection with FAdV-4, and the expression levels of the target proteins were detected by Western Blot. RESULTS: When LMH cells were pretreated with increasing concentrations of Methyl-β-cyclodextrin prior to infection, penton protein levels decreased in a dose-dependent manner. [2] |
| 體內(nèi)活性 | METHODS: To test the antitumor activity in vivo, Methyl-β-cyclodextrin (500 mg/kg) was intraperitoneally injected into NRJ mice bearing PEL tumor BCBL-1 once a day for twenty-one days. RESULTS: Methyl-β-cyclodextrin significantly inhibited the growth and invasion of PEL cells without significant adverse effects. [1] METHODS: To investigate the modulatory effects on collagen, Methyl-β-cyclodextrin (1.25-5.0 mg/mouse) was intradermally injected into the SKH1 mouse twice a week for two months. RESULTS: Methyl-β-cyclodextrin showed potent COL I up-regulatory activity resulting in increased skin thickness. [3] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 55 mg/mL (41.98 mM) |
| 關(guān)鍵字 | Methyl-β-cyclodextrin | Inhibitor | Methylβcyclodextrin | Methyl-b-cyclodextrin | b-Cyclodextrin methyl ethers | Methyl β cyclodextrin | β-Cyclodextrin methyl ethers | inhibit |
| 相關(guān)庫 | 大環(huán)化合物庫 | NO PAINS 化合物庫 | 臨床前化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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