Product Details
| Product Name:
Methoxychlor |
CAS No.:
72-43-5 |
| Purity:
≥95% |
Supply Ability:
10g |
| Release date:
2024/11/19 |
Product Introduction
Bioactivity
| Name | Methoxychlor |
| Description | Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models. |
| Cell Research | Fura-2, a Ca2?-sensitive fluorescent dye, was applied to measure [Ca2?]i. Methoxychlor at concentrations of 0.1-1 μM caused a [Ca2?]i rise in a concentration-dependent manner. Removal of external Ca2? abolished methoxychlor's effect. Methoxychlor-induced Ca2? influx was confirmed by Mn2?-induced quench of fura-2 fluorescence. Methoxychlor-induced Ca2? entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C modulators. Methoxychlor killed cells at concentrations of 10-130 μM in a concentration-dependent fashion. Chelation of cytosolic Ca2? with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent methoxychlor's cytotoxicity. Methoxychlor (10 and 50 μM) induced apoptosis concentration-dependently as determined by using Annexin V/propidium iodide staining |
| In vitro | In HA59T cells, methoxychlor induced a [Ca2?]i rise by inducing Ca2? entry via protein kinase C-sensitive Ca2?-permeable channels, without causing Ca2? release from stores. Methoxychlor also induced apoptosis that was independent of [Ca2?]i rises. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 22.5 mg/mL (65.1 mM)
|
| Keywords | Methoxychlor |
| Related Compound Libraries | Pesticide Compound Library | Bioactive Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$50.00/1kg |
VIP3Y
|
Hebei Fengjia New Material Co., Ltd
|
2023-04-25 |
United States