Methotrexate metabolite NEW
Price | $48 | $77 | $116 |
Package | 25mg | 50mg | 100mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-09 |
Product Details
Product Name: Methotrexate metabolite | CAS No.: 19741-14-1 |
Purity: 99.7% | Supply Ability: 10g |
Release date: 2024/11/09 |
Product Introduction
Bioactivity
名稱 | Methotrexate metabolite |
描述 | Methotrexate metabolite (DAMPA) (DAMPA) is the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist. Methotrexate is used as a chemotherapeutic agent and immunosuppressant. |
體外活性 | Methotrexate metabolite was the most active, with 50% inhibitory concentrations in vitro of 446 ng/ml against the antifolate-sensitive strain and 812 ng/ml against the highly resistant strain under physiological folate conditions. Methotrexate metabolite potentiates the activity of the sulfone dapsone, an inhibitor of dihydropteroate synthase, but not that of chlorcycloguanil, a known inhibitor of dihydrofolate reductase (DHFR)[2]. |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 4 mg/mL (12.30 mM) |
關(guān)鍵字 | Inhibitor | Antifolate | Drug Metabolite | inhibit | Methotrexate metabolite |
相關(guān)產(chǎn)品 | Pemetrexed | Methotrexate | Clofibric acid | Mycophenolate Mofetil | CLOZAPINE N-OXIDE | Monomethyl fumarate | Trimethoprim | Isonicotinic acid | Ampyrone | Nicotinamide N-oxide |
相關(guān)庫 | 抗寄生蟲庫 | 經(jīng)典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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