Melatonin NEW
| Price | $64 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Melatonin | CAS No.: 73-31-4 |
| Purity: 99.79% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Melatonin |
| Description | Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities. |
| In vitro | METHODS: Ten cells were pretreated with EIPA (50 μM) for 1.5 h. Dextran index was measured by Dextran uptake assay. RESULTS: Immortalized but untransformed hTERT-HME1 mammary epithelial cells and MCF10A cells did not exhibit megaloblast efflux in complete medium but stimulated dextran uptake by nutrient deprivation. Although PIK3CB was found to be required for growth factor-stimulated macrocytosis, oncogenic mutations in PIK3CA were sufficient to induce constitutive macrocytosis in mouse embryonic fibroblast MEFs and untransformed MCF10A cells. [1] METHODS: MKN28 cells were treated with EIPA (5-100 μM) for 48 h. Cell proliferation was detected by cell count. RESULTS: Cell exposure to EIPA inhibited the proliferation of MKN28 cells in a dose- and time-dependent manner. [2] |
| In vivo | METHODS: To assay in vivo activity, EIPA (10 mg/kg) was injected intraperitoneally into BALB/c mice bearing 4T1 xenografts, and 70 kD FITC-Ficoll was injected into the tumors 1 h later. The mice were necropsied 1 h after Ficoll injection, and the tumors were excised and frozen in OCT. RESULTS: EIPA-sensitive 70 kD FITC-Ficoll uptake was observed in in situ homozygous 4T1 tumors of BALB/c mice, suggesting that AMPK activation or other signals are sufficient to trigger the formation of large fusions in vivo. [1] |
| Storage | store at low temperature,keep away from direct sunlight,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+90% Saline : 1.16 mg/mL (4.99 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. DMSO : 55 mg/mL (236.78 mM) |
| Keywords | Mitophagy | Mitochondrial Autophagy | Melatonin Receptor | Melatonin | Inhibitor | inhibit | Endogenous Metabolite | Autophagy | Apoptosis |
| Inhibitors Related | Sucrose | Dextran sulfate sodium salt (MW 4500-5500) | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Tributyrin | Ferulic Acid | Paeonol | Glycerol | Thymidine | Oleic acid | 3-Indoleacetic acid |
| Related Compound Libraries | Anti-Tumor Natural Product Library | EMA Approved Drug Library | Kinase Inhibitor Library | Drug Repurposing Compound Library | Natural Product Library for HTS | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Approved Drug Library | Human Endogenous Metabolite Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Gut Microbial Metabolite Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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