Manufacturer Provide Mavacamten Myk-461 (SAR-439152) Powder CAS 1642288-47-8 

Introduction

Product Name: Mavacamten

Other Name :Mavacamten (MYK-461

CAS NO:1642288-47-8

Purity: 99%min
Appearance:White crystalline powder

Molecular formula:C15H19N3O2

MW:273.33

Density:1.19±0.1 g/cm3(Predicted)

Storage :Keep in dark place,Inert atmosphere,Room temperature

MYK-461 reduces the activity of homeostasis ATPASE by inhibiting the phospharic acid release rate of β -myocardial myosin -S1. MYK-461 regulates several steps in the myosin chemo-mechanical cycle: in addition to reducing the rate-limiting step (phospharic acid release) in this cycle, MYK-461 also reduces the number of myosin-S1 heads that interact with actin filaments during the transition from weak to strong binding states. MYK-461 also reduced the binding rate of myosin to ADP-actin and the release rate of ADP from Myosin-S1.