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Postion:Product Catalog >LY3200882
LY3200882
  • LY3200882

LY3200882 NEW

Price $39 $89 $147
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: LY3200882 CAS No.: 1898283-02-7
Purity: 99.46% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameLY3200882
DescriptionLY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
In vitroLY3200882 effectively inhibits TGFβ-mediated SMAD phosphorylation in tumor and immune cells in vitro, demonstrates anti-metastatic activity in migration assays, and rescues TGFβ1 or T regulatory cell-suppressed naive T cell activity, restoring proliferation in immune suppression assays [1].
In vivoLY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 4.36 mg/mL (10 mM), Sonication is recommended.
KeywordsAnti-cancer | ALK5 | TGFβRI | ATP-competitive | inhibit | immune | phosphorylation | LY3200882 | Transforming growth factor beta receptors | anti-metastatic | TGF-β Receptor | LY-3200882 | SMAD | serine-threonine | Inhibitor | LY 3200882
Inhibitors RelatedMonocrotaline | SB-431542 | DMH-1 | RepSox | Chromenone 1 | LY-364947 | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone | Pentabromophenol
Related Compound LibrariesHighly Selective Inhibitor Library | Bioactive Compound Library | Anti-Obesity Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Bioactive Compounds Library Max | TGF-beta/Smad Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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