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Postion:Product Catalog >LY2510924 acetate(1088715-84-7 free base)
LY2510924 acetate(1088715-84-7 free base)
  • LY2510924 acetate(1088715-84-7 free base)

LY2510924 acetate(1088715-84-7 free base) NEW

Price $162 $323 $483
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: LY2510924 acetate(1088715-84-7 free base) Purity: 97.32%
Supply Ability: 10g Release date: 2024/11/19

Product Introduction

Bioactivity

NameLY2510924 acetate(1088715-84-7 free base)
DescriptionLy2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
In vitroIn human lymphoma U937 cells expressing endogenous CXCR4, LY2510924 acetate inhibited SDF-1-induced cell migration with IC50 value of 0.26 nmol/L and inhibited SDF-1/CXCR4-mediated intracellular signaling. LY2510924 acetate exhibited a concentration-dependent inhibition of SDF-1-stimulated phospho-ERK and phospho-Akt in tumor cells.
In vivoLY2510924 acetate showed dose-dependent inhibition of tumor growth in human xenograft models developed with non-Hodgkin lymphoma, renal cell carcinoma, lung, and colon cancer cells that express functional CXCR4. In MDA-MB-231, a breast cancer metastatic model, LY2510924 acetate inhibited tumor metastasis by blocking migration/homing process of tumor cells to the lung and by inhibiting cell proliferation after tumor cell homing.
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 60 mg/ml (47.98 mM)
KeywordsLY2510924 acetate(1088715847 free base) | LY2510924 acetate(1088715 84 7 free base) | LY2510924 acetate(1088715-84-7 free base) | LY-2510924 acetate(1088715-84-7 free base)
Inhibitors RelatedTannic acid | Nicotinamide N-oxide
Related Compound LibrariesBioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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