LTX315 acetate NEW
| Price | $68 | $97 | $139 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: LTX315 acetate | Purity: 99.93% |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | LTX315 acetate |
| Description | LTX315 acetate (Oncopore acetate) is an oncolytic peptide with potent anticancer activity, with IC50 values of 34.3 μM for MRC-5, 8.3 μM for A20, and 11 μM for AT84, respectively. |
| In vitro | LTX315 acetate induces rapid killing of cancer cells. LTX315 acetate is equally potent against drug-resistant cancer cells, non-toxic to erythrocytes, shows high plasma protein binding, and can be rapidly degraded to non-toxic metabolites. The oncolytic activity of LTX315 acetate results from direct lysis of the plasma membrane and permeabilization of the mitochondrial membrane, resulting in cell death due to necrosis and release of tumor antigens. Treatment of cancer cells with LTX315 acetate results in the release of several danger signals (DAMPs) that are associated with immunogenic cell death and stimulation of adaptive immune responses[1]. |
| In vivo | Intratumoral administration of LTX315 acetate resulted in tumor necrosis and immune cell infiltration into the tumor parenchyma, followed by complete tumor regression in most animals. LTX-315 induces the release of risk-associated molecular patterning molecules, such as high mobility group box-1 proteins, in vitro, followed by upregulation of pro-inflammatory cytokines such as interleukin (IL) 1β, IL6, and IL18 in vivo. Animals cured by LTX315 acetate treatment were protected from rechallenging with live intradermal and intravenous B16 tumor cells [2]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Ruxotemitide Acetate | LTX315 acetate | LTX-315 acetate | LTX-315 Acetate | LTX 315 Acetate | KKWWKKW-Dip-K-NH2 Acetate | Oncopore Acetate | LTX315 Acetate |
| Related Compound Libraries | Bioactive Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Clinical Compound Library | Peptide Compound Library | Drug Repurposing Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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