Lovastatin NEW
| Price | $34 | $46 | $66 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Lovastatin | CAS No.: 75330-75-5 |
| Purity: 99.72% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Lovastatin |
| Description | Lovastatin (MK-803) is an HMG-CoA reductase inhibitor (IC50=3.4 nM). Lovastatin lowers cholesterol and is commonly used as a lipid-lowering agent in the treatment of hypercholesterolemia. |
| Cell Research | Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2]. |
| In vitro | METHODS: PEL cell lines BC3 and BCBL1 were treated with Lovastatin (3-30 μM) for 24-48 h. Cell viability was measured using Trypan blue exclusion. RESULTS: A dose- and time-dependent decrease in cell viability after Lovastatin treatment was observed in both PEL cell lines. [1] METHODS: The human breast cancer cell lines MDAMB231 and MDAMB468 were treated with Lovastatin (8 μg/mL) for 48 h. The expression levels of target proteins were detected using Western Blot. RESULTS: Several proteins involved in the regulation of cell proliferation and cell cycle activity present in breast cancer cells were significantly altered when exposed to Lovastatin. Changes in the expression of two cell cycle regulatory proteins, prohibitin and MCM7, which are associated with E2F activity, were also detected. [2] |
| In vivo | METHODS: To assay antitumor activity in vivo, Lovastatin (25-50 mg/kg) was administered intraperitoneally to C3(1)/TAg transgenic mice in a breast cancer model three times per week for 4-12 weeks. RESULTS: Four weeks of treatment with Lovastatin did inhibit precancerous mammary intraepithelial neoplasia (MIN) formation in vivo, but did not inhibit invasive carcinoma formation in a C3(1)/SV40-TAg transgenic model of mammary carcinomas. [3] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (111.24 mM) Ethanol : 20.2 mg/mL (50 mM)), Heating is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.05 mg/mL (10.01 mM), Suspension. Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. |
| Keywords | MK 803 | Autophagy | Lovastatin | Inhibitor | Ferroptosis | MK803 | HMG-CoA Reductase (HMGCR) | inhibit |
| Inhibitors Related | Hydroxychloroquine | Guanidine hydrochloride |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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