Lonidamine NEW
| Price | $33 | $45 | $58 |
| Package | 2mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-16 |
Product Details
| Product Name: Lonidamine | CAS No.: 50264-69-2 |
| Purity: 97.36% | Supply Ability: 10g |
| Release date: 2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | Lonidamine |
| 描述 | Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). |
| 體外活性 | In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth. |
| 體內活性 | In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (186.82 mM), Sonication is recommended. Ethanol : 1.6 mg/mL (5 mM) |
| 關鍵字 | mitochondrial complex | AF-1890 | lactate | lung fibrosis | Mitochondrial | Hexokinase | Mitochondrial Metabolism | Lonidamine | A549 | Inhibitor | Apoptosis | H2030BrM3 | AF 1890 | inhibit | pulmonary fibrosis |
| 相關產品 | Stavudine | 5-Fluorouracil | Imeglimin hydrochloride | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| 相關庫 | 經典已知活性庫 | 神經退行性疾病化合物庫 | 激酶抑制劑庫 | 抗癌臨床化合物庫 | 藥物功能重定位化合物庫 | FDA 上市激酶抑制劑庫 | 抗癌上市藥物庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌藥物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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