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Postion:Product Catalog >Lomitapide
Lomitapide
  • Lomitapide

Lomitapide NEW

Price $59 $96 $148
Package 2mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Lomitapide CAS No.: 182431-12-5
Purity: 99.77% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameLomitapide
DescriptionLomitapide (AEGR-733) is a small molecule inhibitor of microsomal triglyceride transfer protein (MTP), an enzyme located in the lumen of the endoplasmic reticulum responsible for absorbing dietary lipids and transferring triglycerides onto apolipoprotein B (apo-B) in the assembly of very-low-density lipoprotein.
In vitroLomitapide is an oral microsomal triglyceride transfer protein (MTP) inhibitor indicated for the treatment of patients with HoFH, a rare form of hypercholesterolemia that can lead to premature atherosclerotic disease. Lomitapide undergoes hepatic metabolism through cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP3A4 substrates including atorvastatin and simvastatin[2].
In vivoLomitapide, either as monotherapy or in combination with other lipid-lowering agents, notably reduces low-density lipoprotein cholesterol (LDL-C) levels by over 50%. However, its use is accompanied by significant gastrointestinal side effects and increased hepatic fat. The 50-mg capsule of lomitapide has a bioavailability of 7.1%, and its mean half-life is approximately 39.7 hours[2]. Administration of a single dose of lomitapide can decrease serum triglycerides by 35% and 47% at dosages of 0.3 and 1 mg/kg, respectively. Moreover, multiple-dose regimens have shown a dose-dependent reduction in triglycerides (71%-87%), nonesterified fatty acids (33%-40%), and LDL-C (26-29%)[3].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 93 mg/mL (134.3 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : 93 mg/mL (134.3 mM)
KeywordsLomitapide | AEGR 733 | BMS 201038 | Inhibitor | AEGR733 | BMS201038 | inhibit
Inhibitors RelatedAnacetrapib | Granotapide | BMS-212122 | KD-026 | Torcetrapib | NAMI-A | Dirlotapide | Obicetrapib | Dalcetrapib | Lomitapide Mesylate
Related Compound LibrariesBioactive Compound Library | ReFRAME Related Library | EMA Approved Drug Library | Anti-Obesity Compound Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Lipid Metabolism Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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