LMK-235 NEW
| Price | $46 | $72 | $142 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-14 |
Product Details
| Product Name: LMK-235 | CAS No.: 1418033-25-6 |
| Purity: 99.24% | Supply Ability: 10g |
| Release date: 2024/11/14 |
Product Introduction
Bioactivity
| 名稱 | LMK-235 |
| 描述 | LMK-235 is a potent HDAC inhibitor, and is used in cancer research. |
| 細(xì)胞實驗 | The rate of cell survival under the action of test substances is evaluated by an improved MTT assay. The assay is based on the ability of viable cells to metabolize yellow MTT to violet formazan that can be detected spectrophotometrically. In brief, A2780, Cal27, Kyse510, and MDA-MB-231 cell lines are seeded at a density of 5000, 7000, 8000, and 10 000 cells/well in 96-well plates. After 24 h, cells are exposed to increased concentrations of the test compounds. Incubation is ended after 72 h, and cell survival is determined by addition of MTT solution (5 mg/mL in phosphate buffered saline). The formazan precipitate is dissolved in DMSO. Absorbance s measured at 544 and 690 nm in a FLUOstar microplate reader. (Only for Reference) |
| 激酶實驗 | HDAC IC50 Profiling: The in vitro inhibitory activity of compounds against seven human HDAC isoforms (1, 2, 4 C2A, 5 C2A, 6, 8, and 11) are performed with a fluorescent based assay according to the company's standard operating procedure. The IC50 values are determined using 10 different concentrations with 3-fold serial dilution starting at 10 μM. TSA and vorinostat are used as reference compounds. |
| 體內(nèi)活性 | LMK-235 demonstrates significant cytotoxicity against the breast cancer cell line MDA-MB-231, the oral cancer cell line Cal27, and the esophageal cancer cell line Kyse510, notably enhancing the cytotoxic effect of cisplatin. Additionally, LMK-235 exhibits nanomolar-level activity across various life-cycle stages of Plasmodium species. It induces histone deacetylase (HDAC) inhibition in human cancer cell lines with varying sensitivity to cisplatin compounds, achieving an IC50 of less than 1 μM. |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 2.94 mg/mL (10 mM), Sonication is recommended. Ethanol : 29.4 mg/mL (100 mM) |
| 關(guān)鍵字 | HDAC | LMK-235 | LMK 235 | Histone deacetylases | Inhibitor | inhibit |
| 相關(guān)產(chǎn)品 | Valproic acid sodium salt | Panobinostat | Theophylline monohydrate | Sodium 4-phenylbutyrate | Vorinostat | Acefylline | Curcumin | Valproic Acid | Parthenolide | 4-Phenylbutyric acid | Theophylline | Methyl L-histidinate dihydrochloride |
| 相關(guān)庫 | 細(xì)胞重編程化合物庫 | 經(jīng)典已知活性庫 | 癌細(xì)胞分化化合物庫 | HIF-1化合物庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | 抗衰老化合物庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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