Lithocholic acid NEW
| Price | $50 |
| Package | 1mL |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-06 |
Product Details
| Product Name: Lithocholic acid | CAS No.: 434-13-9 |
| Purity: 99.93% | Supply Ability: 10g |
| Release date: 2024/11/06 |
Product Introduction
Bioactivity
| 名稱 | Lithocholic acid |
| 描述 | Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic. |
| 激酶實(shí)驗(yàn) | Competitive ligand binding assay.: Ligand binding is performed using lysates from COS-7 cells transfected with expression plasmids for VDR or RXRα. Binding is performed overnight at 4°C in lysate buffer with 0.71 nM (18 Ci/mmol) [3H]1,25(OH)2D3 and bile acid competitor. Unbound [3H]1,25(OH)2D3 is removed by adsorption to dextran-coated charcoal and the supernatant removed for scintillation counting. Ki values are calculated from a computer fit of competition curves from triplicate assays. |
| 體外活性 | In a mouse cancer model induced by DMH (dimethylhydrazine), LCA effectively inhibits apoptosis almost completely in the precancerous colon. When administered to rodents, LCA and its conjugates cause intrahepatic cholestasis, a pathological state characterized by reduced bile flow and the accumulation of bile components in the liver and blood. Lithocholic acid activates the vitamin D receptor, inducing the expression of CYP3A, a cytochrome P450 enzyme that detoxifies LCA in the liver and intestines. |
| 體內(nèi)活性 | Lithocholic acid exhibits tumor-promoting activity and inhibits mammalian DNA polymerase β with an IC50 of 15 μM. It causes cholestasis (cessation or obstruction of bile flow) within the liver. Furthermore, lithocholic acid activates the Pregnane X Receptor (PXR), and the severe liver damage induced by LCA can be mitigated by the activation of PXR. Additionally, lithocholic acid directly binds to the vitamin D receptor with a Ki of 29 μM, activating it with a sensitivity higher than that for other nuclear receptors (e.g., PXR, FXR), with a Ki of 30 μM. This activation offers protection from its toxic effects. |
| 存儲(chǔ)條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | Ethanol : 44 mg/mL (116.8 mM) DMSO : 55 mg/mL (146.05 mM) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| 關(guān)鍵字 | Autophagy | Apoptosis | Lithocholic acid | inhibit | Endogenous Metabolite | Inhibitor | 3a-Hydroxy-5b-cholanic acid | 3alpha-Hydroxy-5beta-cholanic acid |
| 相關(guān)產(chǎn)品 | Sucrose | Hydroxychloroquine | Daidzein | Guanidine hydrochloride | Tributyrin | Ferulic Acid | Paeonol | Glycerol | Thymidine |
| 相關(guān)庫(kù) | 抗癌天然產(chǎn)物庫(kù) | 微生物天然產(chǎn)物庫(kù) | 抗癌上市藥物庫(kù) | FDA 上市藥物庫(kù) | 高通量篩選天然產(chǎn)物庫(kù) | 人內(nèi)源代謝化合物庫(kù) | 抗感染天然產(chǎn)物庫(kù) | 抗衰老化合物庫(kù) | 腸道微生物代謝化合物庫(kù) | 抗癌藥物庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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