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Postion:Product Catalog >API>Digestive system drugs>Laxatives and Antidiarrheal Medicines>Lidamidine
Lidamidine
  • Lidamidine

Lidamidine NEW

Price $195 $437 $646
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-06

Product Details

Product Name: Lidamidine CAS No.: 66871-56-5
Purity: 99.84% Supply Ability: 10g
Release date: 2024/11/06

Product Introduction

Bioactivity

名稱Lidamidine
描述Lidamidine (Lidamidinum) is an effective antidiarrheal agent that inhibits intestinal secretion, reduces intestinal transit, and inhibits smooth muscle contraction.
體內(nèi)活性Fasted male rats were anesthetised and equipped with an intraluminal cannula positioned at the proximal end of a 10 cm fluid-filled segment of the ascending colon (basal pressure, 10 cm H2O). Intraluminal pressure was monitored by a transducer attached to a closed fluid-filled system. All drugs were administered intravenously by slow infusion. A regular pattern of distinct contractile complexes was observed over a 70 min period. These contractions increased intraluminal pressure to 39 +/- 1.2 cm H2O (mean +/- S.E.), occurred at a frequency of 0.3 per min and lasted from 1 to 2.5 min. Inhibition of these contractile patterns was observed with either atropine (0.1 mg/kg) or lidamidine (3.0 mg/kg). A 20 min pretreatment with idazoxan (3.0 mg/kg) antagonized lidamidine's but not atropine's effect. Trimazosin (1 mg/kg) or propranolol (0.3 mg/kg) pretreatment did not antagonize the lidamidine-generated inhibition[1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 5 mg/mL (22.7 mM)
關(guān)鍵字Lidamidine
相關(guān)庫(kù)經(jīng)典已知活性庫(kù) | ReFRAME 相關(guān)化合物庫(kù) | 已知活性化合物庫(kù) | 人代謝物化合物庫(kù)

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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Product name Price   Suppliers Update time
$2500.00/100mg
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TargetMol Chemicals Inc.
2024-10-28
  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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