Levofloxacin NEW
| Price | $48 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: Levofloxacin | CAS No.: 100986-85-4 |
| Purity: 97.63% | Supply Ability: 10g |
| Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | Levofloxacin |
| Description | Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that inhibits the superhelical activity of bacterial DNA rotamase and prevents DNA replication. Levofloxacin is a broad-spectrum antibiotic used for the treatment of a wide range of bacterial infections. |
| In vitro | METHODS: Bladder cell lines SV-HUC-1 and T24 were treated with Levofloxacin (25-800 μg/mL) for 24-48 h. Cell viability was measured by MTT assay. RESULTS: Levofloxacin is cytotoxic in a dose- and time-dependent manner. [1] METHODS: IL-1β-stimulated inflammatory FLS cells were treated with Levofloxacin (14-224 μM) for 24 h, and gene expression levels were measured by RT-qPCR. RESULTS: When IL-1β-stimulated inflammatory FLS were treated with Levofloxacin for 24 h, the mRNA levels of MMP-1 and MMP-3 were increased in a concentration-dependent manner, and the mRNA expression level of TIMP-1 was also increased accordingly. In addition, the expression of pro-inflammatory cytokines IL-6 and COX-2 decreased in a concentration-dependent manner, while PGE2 did not show any significant changes. In addition, the expression levels of Caspase-3 and Caspase-8 increased in a concentration-dependent manner. [2] |
| In vivo | METHODS: To study in vivo antimicrobial activity, Levofloxacin (100 mg/kg) and Imipenem (100 mg/kg) were administered intraperitoneally four times at 3 h intervals in the Acinetobacter baumannii pneumonia mouse model. RESULTS: For Levofloxacin-sensitive strains, Levofloxacin and Imipenem were less bactericidal, with a slight reduction in lung bacterial counts compared to values at the start of treatment. The combination of Levofloxacin and Imipenem did not increase bactericidal activity. All regimens tested significantly reduced mortality compared to controls. [3] |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 12.5 mg/mL (34.59 mM) Ethanol : 2 mg/mL (5.5 mM) H2O : 9 mg/mL (24.9 mM) |
| Keywords | Orthopoxvirus | BK Viremia | Topoisomerase | inhibit | Inhibitor | Levofloxacin | Antibiotic | DNA gyrase | airway inflammation | DNA/RNA Synthesis | Bacterial | Ofloxacin | chronic periodontitis |
| Inhibitors Related | Neomycin sulfate | Ampicillin sodium | Kanamycin sulfate | Sulfamethoxazole sodium | Doxycycline | Dimethyl sulfoxide |
| Related Compound Libraries | Bioactive Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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