LDHA-IN-3 NEW
| Price | $50 | $122 | $196 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-01 |
Product Details
| Product Name: LDHA-IN-3 | CAS No.: 227010-33-5 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2024/11/01 |
Product Introduction
Bioactivity
| 名稱 | LDHA-IN-3 |
| 描述 | LDHA-IN-3 (1-(phenylseleno)-4-(trifluoromethyl) benzene) is a potent non-competitive lactate dehydrogenase (LDHA) inhibitor with an IC50 value of 145.2 nM.LDHA-IN-3 is a selenobenzene compound that can be used in cancer research. |
| 體外活性 | LDHA-IN-3 (PSTMB) (0~500 μM; 48 h; MCF-7 cells) has cytotoxic effects.[1] PSTMB (0.01~1 μM) has a dose-dependent inhibitory effect on LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots.[1] PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage.[1] PSTMB efficiently binds to LDHA protein. PSTMB induces intrinsic pathway-mediated apoptosis in cancer cells through the production of mitochondrial ROS.[1] |
| 存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 60 mg/mL (199.22 mM), Sonication is recommended. |
| 關鍵字 | LDHA-IN-3 | LDHAIN3 | LDHA IN 3 |
| 相關產品 | Disulfiram | Methotrexate | Rotenone | Mycophenolate Mofetil | Ribavirin | 4-Diethylaminobenzaldehyde | Benzyl alcohol | Isomalt | Isoniazid | Ivosidenib |
| 相關庫 | 經典已知活性庫 | 抑制劑庫 | 已知活性化合物庫 | 抗癌化合物庫 | 抗癌活性化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36?Washington?Street, Wellesley?Hills
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