Larazotide acetate NEW
Price | $39 | $80 | $128 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2024-11-19 |
Product Details
Product Name: Larazotide acetate | CAS No.: 881851-50-9 |
Purity: 95.53% | Supply Ability: 10g |
Release date: 2024/11/19 |
Product Introduction
Bioactivity
Name | Larazotide acetate |
Description | Larazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state. |
In vitro | Larazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines. |
In vivo | Larazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice. |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O : 16.67 mg/mL (21.21 mM), Sonication is recommended. DMSO : 3.2 mg/mL (4.07 mM), Sonication and heating are recommended. |
Keywords | inhibit | Larazotide acetate | Larazotide | Larazotide Acetate | Inhibitor | Gap Junction Protein |
Inhibitors Related | Meclofenamic acid sodium | Carvedilol phosphate hemihydrate | Rotigaptide TFA(355151-12-1 free base) | Gap 27 | Gap 26 | Danegaptide Hydrochloride | TAT-Gap19 acetate | Carbenoxolone disodium | Gap19 | Carbenoxolone |
Related Compound Libraries | Bioactive Compound Library | Pediatric Drug Library | Drug Repurposing Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Since: 2011-01-07
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