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Postion:Product Catalog >Organic Chemistry>Carboxylic acids and derivatives>Larazotide acetate
Larazotide acetate
  • Larazotide acetate

Larazotide acetate NEW

Price $39 $80 $128
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-19

Product Details

Product Name: Larazotide acetate CAS No.: 881851-50-9
Purity: 95.53% Supply Ability: 10g
Release date: 2024/11/19

Product Introduction

Bioactivity

NameLarazotide acetate
DescriptionLarazotide acetate is a synthetic peptide. It functions as a tight junction regulator and reverses leaky junctions to their normally closed state.
In vitroLarazotide acetate inhibits the AT-1002-induced TEER reduction and TJ opening in Caco-2 cells and it also inhibits the redistribution and rearrangement of zonula occludens-1 (ZO-1) and actin caused by AT-1002 and gliadin fragments in Caco-2 and IEC6 cells. Larazotide acetate inhibits the translocation of a gliadin 13-mer peptide, which has been implicated in celiac disease, across Caco-2 cell monolayers. Apically applied Larazotide acetate inhibits the increase in TJ permeability elicited by basolaterally applied cytokines.
In vivoLarazotide acetate inhibits gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure when tested in vivo in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice.
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationH2O : 16.67 mg/mL (21.21 mM), Sonication is recommended.
DMSO : 3.2 mg/mL (4.07 mM), Sonication and heating are recommended.
Keywordsinhibit | Larazotide acetate | Larazotide | Larazotide Acetate | Inhibitor | Gap Junction Protein
Inhibitors RelatedMeclofenamic acid sodium | Carvedilol phosphate hemihydrate | Rotigaptide TFA(355151-12-1 free base) | Gap 27 | Gap 26 | Danegaptide Hydrochloride | TAT-Gap19 acetate | Carbenoxolone disodium | Gap19 | Carbenoxolone
Related Compound LibrariesBioactive Compound Library | Pediatric Drug Library | Drug Repurposing Compound Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Preclinical Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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