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Postion:Product Catalog >Lanraplenib
Lanraplenib
  • Lanraplenib

Lanraplenib NEW

Price $47 $68 $101
Package 1mg 2mg 5mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-15

Product Details

Product Name: Lanraplenib CAS No.: 1800046-95-0
Purity: 99.42% Supply Ability: 10g
Release date: 2024/11/15

Product Introduction

Bioactivity

名稱Lanraplenib
描述Lanraplenib (GS-9876) is a highly selective and orally active SYK inhibitor (IC50=9.5 nM) being developed for treating inflammatory diseases. It inhibits SYK activity in platelets via the glycoprotein VI (GPVI) receptor without prolonging bleeding time (BT) in monkeys or humans.
體外活性Lanraplenib (GS-9876) inhibits glycoprotein VI (GPVI)-induced phosphorylation of linker for activation of T cells and phospholipase Cγ2, platelet activation and aggregation in human whole blood, and platelet binding to collagen under arterial flow [2]. Lanraplenib inhibits anti-IgM stimulated phosphorylation of AKT, BLNK, BTK, ERK, MEK, and PKCδ in human B cells (EC50s: 24-51 nM). Lanraplenib inhibits anti-IgM mediated CD69 and CD86 expression on B-cells (EC50: 112±10 nM and 164±15 nM, respectively) and anti-IgM /anti-CD40 co-stimulated B cell proliferation (EC50: 108±55 nM). In human macrophages, Lanraplenib inhibits IC-stimulated TNFα and IL-1β release (EC50: 121±77 nM and 9±17 nM, respectively) [1].
存儲(chǔ)條件Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
溶解度DMSO : 41.67 mg/mL (93.96 mM), Sonication is recommended.
關(guān)鍵字Lanraplenib | Syk | Spleen tyrosine kinase | Inhibitor | GS9876 | GS 9876 | inhibit
相關(guān)產(chǎn)品Fostamatinib | R112 | Syk-IN-3 | Ellagic acid | Piceatannol | Cerdulatinib | PRT062607 hydrochloride | Fostamatinib Disodium | ANTHRAQUINONE-2-CARBOXYLIC ACID | GSK1904529A | Cerdulatinib hydrochloride | R406 free base
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Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36?Washington?Street, Wellesley?Hills
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