L-Homocysteine thiolactone hydrochloride NEW
| Price | $44 | $63 | $89 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-19 |
Product Details
| Product Name: L-Homocysteine thiolactone hydrochloride | CAS No.: 31828-68-9 |
| Supply Ability: 10g | Release date: 2024/11/19 |
Product Introduction
Bioactivity
| Name | L-Homocysteine thiolactone hydrochloride |
| Description | L-Homocysteine thiolactone hydrochloride is neurotoxic and can induce epilepsy and Alzheimer's disease. |
| In vitro | At a concentration of 0.25 mM and after 24 h incubation with L-Homocysteine thiolactone hydrochloride showed around 40% of cell death. Using 1 mM of L-Homocysteine thiolactone hydrochloride and after 24 h incubation up to 80% of cell death was detected. HUVEC cells were therefore incubated with increasing concentrations of Hcy (1 mM–10 mM) or L-Homocysteine thiolactone hydrochloride (0.25 mM–1 mM) for different times. None of the Hcy or L-Homocysteine thiolactone hydrochloride concentrations tested had an effect on TNF-α or IL-1α secretion. However, Hcy or L-Homocysteine thiolactone hydrochloride promoted the release of IL-8 starting from 3 h and increasing according to a dose-time dependent manner. [3] |
| In vivo | L-Homocysteine thiolactone hydrochloride dissolved in PBS was injected i.p., into 4-12-week-old mice (40-600 nmol/g body weight). To determine how Pon1 affects its turnover in vivo, L-Homocysteine thiolactone hydrochloride was injected i.p. into Pon1?/? and Pon1+/+ mice, and Hcy-thiolactone kinetics in plasma were monitored. A non-toxic dose of 600 nmol L-Homocysteine thiolactone hydrochloride /g body weight in most experiments, but similar results were obtained with doses as low as 40 nmol/g body weight. This shows that in Pon1?/? mice Hcy-thiolactone metabolism is not impaired during its transit from the intraperitoneal cavity to the bloodstream and suggests that Pon1 has a negligible contribution to Hcy-thiolactone turnover in membranes surrounding the intraperitoneal cavity. [4] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 20 mg/mL (130.18 mM), Sonication is recommended. DMSO : 100 mg/mL (650.91 mM), Sonication is recommended. |
| Keywords | LHomocysteine thiolactone hydrochloride | L Homocysteine thiolactone hydrochloride | L-Homocysteine thiolactone Hydrochloride |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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