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Postion:Product Catalog >KDM5-C70
KDM5-C70
  • KDM5-C70

KDM5-C70 NEW

Price $56 $81 $143
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2024-11-18

Product Details

Product Name: KDM5-C70 CAS No.: 1596348-32-1
Purity: 99.12% Supply Ability: 10g
Release date: 2024/11/18

Product Introduction

Bioactivity

NameKDM5-C70
DescriptionKDM5-C70 is an ethyl ester derivative of KDM5-C49 and functions as an effective, cell-permeable, pan-KDM5 histone demethylase inhibitor. It exhibits an antiproliferative effect in myeloma cells and induces a genome-wide elevation of H3K4me3 levels.
In vitroKDM5-C70 (50 μM; 7 days; MM.1S myeloma cells) treatment reduces the level of phosphorylation of retinoblastoma protein (Rb) while leaving the total level of phosphorylated Rb (pRb) unchanged, indicating impairment of cell cycle progression. KDM5-C70 (1 nM-10 μM; 7 days; MM.1S myeloma cells) treatment displays antiproliferative effects after 7 days of treatment at elevated concentrations (estimated 50% reduction of viability/proliferation for KDM5-C70 at ~20 μM). Chromatin immunoprecipitation followed by next-generation sequencing displays an enhanced H3K4me3 level around transcription start sites with KDM5-C70 but little change with GSK467A at 50 μM inhibitor concentrations [1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 250 mg/mL (743.10 mM), Sonication is recommended.
KeywordsKDM5-C70 | KDM5-C49 | Histone Demethylase | JARID1 | retinoblastoma | inhibit | KDM5 C70 | KDM-5-C70 | phosphorylation | KDM5C70 | KDM5 | Inhibitor | H3K4me3 | antiproliferative
Inhibitors RelatedLSD1-IN-24 | Tranylcypromine hemisulfate | DDP-38003 dihydrochloride | GSK-LSD1 dihydrochloride | GSK-J4 | FY-21 | Daminozide | Zavondemstat | AS8351 | Procaine hydrochloride | JIB-04 | KDM4-IN-4
Related Compound Libraries組蛋白修飾化合物庫 | 經(jīng)典已知活性庫 | 表觀遺傳庫 | 抑制劑庫 | NO PAINS 化合物庫 | 已知活性化合物庫

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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